The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Twenty‐four hour profiles of four hormones under constant routine
Open accessAbstract
Abstract We studied the circadian features of melatonin, cortisol, thyroid stimulating hormone (TSH), and growth hormone (GH) together with rectal temperature during 36 h continuous forced wakefulness without physical exercise under dim light condition (constant routine). Subjects consisted of four healthy men aged 22–24 years. Blood sampling was conducted hourly, and food and water were supplied bi‐hourly during the constant routine. Melatonin, TSH and cortisol displayed clear circadian rhythms under constant routine condition. While GH secretion was unlikely to be driven solely by the circadian pacemaker, its suppression round BT nadir may indicate that GH secretion was modulated to some extent by circadian rhythm.
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The 24-h rhythm of cortisol is driven by the central circadian pacemaker located in the suprachiasmatic nucleus, which entrains peripheral clocks throughout the body.
“The 24-h rhythm of cortisol expressed in humans is driven by the central circadian pacemaker located in the suprachiasmatic nucleus [56, 57], which entrains all other peripheral clocks throughout the body to coordinate bodily processes with the environment [58, 59].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [56]
The Discussion (page unavailable) says cortisol showed a clear circadian rhythm under constant routine and that its 24-hour secretion pattern was controlled basically by the circadian pacemaker. The paper does not identify that pacemaker as being in the suprachiasmatic nucleus. The sentence cites other sources for the separate claim about peripheral clocks. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe 24-h rhythm of cortisol is driven by the central circadian pacemaker.
“Although the 24-h rhythm of cortisol is driven by the central circadian pacemaker [56, 57]”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [56]
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Citations
Cites
The Statistical Analysis of Circadian Phase and Amplitude in Constant-Routine Core-Temperature Data
Brown, E. N., & Czeisler, C. A. (1992) · Journal of Biological Rhythms · doi:10.1177/074873049200700301 · Cited by 224
Sadamatsu, M., Kato, N., Iida, H., Takahashi, S., Sakaue, K., Takahashi, K., Hashida, S., & Ishikawa, E. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00797.x · Cited by 31
Schulz, P., Lustenberger, S., Agosti, R. D., et al. (1994) · Chronobiology International · doi:10.3109/07420529409057254 · Cited by 10
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Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80
“The 24-h rhythm of cortisol expressed in humans is driven by the central circadian pacemaker located in the suprachiasmatic nucleus [56, 57], which entrains all other peripheral”
BackgroundRoelfsema, F., Pereira, A. M., Adriaanse, R., Endert, E., Fliers, E., Romijn, J. A., & Veldhuis, J. D. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1959 · Cited by 45
Metadata
- Authors
- UCHIYAMA, M., ISHIBASHI, K., ENOMOTO, T., NAKAJIMA, T., SHIBUI, K., HIROKAWA, G., & OKAWA, M.
- Affiliations
- National Institute of Mental Health (US)
- National Center of Neurology and Psychiatry (JP)
- Teikyo University Hospital, Mizonokuchi (JP)
- Corresponding author
- UCHIYAMA, MAKOTO
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 1998-04
- Volume
- 52
- Issue
- 2
- Pages
- 241-243
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1994492514
- Cited by
- 23
- References
- 3
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2022: 2 · 2020: 1 · 2017: 3 · 2016: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, constant routine, melatonin, cortisol, thyroid-stimulating hormone, growth hormone, body temperature, dim light, circadian pacemaker, growth hormone suppression
- MeSH terms
- Adult, Body Temperature Regulation, Circadian Rhythm, Humans, Hydrocortisone, Male, Melatonin, Reference Values, Sleep Stages, Thyrotropin, Wakefulness, Human Growth Hormone
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