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Efficacy of milnacipran on cognitive dysfunction with post‐stroke depression: Preliminary open‐label study
Open accessAbstract
The aim of this study was to assess the therapeutic efficacy of the serotonin norepinephrine reuptake inhibitor (SNRI), milnacipran, on both cognitive impairment and depression in post-stroke depression (PSD) patients. A total of 18 PSD patients, approximately 3 months after stroke, were divided into two groups, milnacipran and control. A total of 10 patients were assigned to the milnaciprane group and eight were assigned to control group. Their cognitive impairment and mood symptoms were measured using the Mini-Mental State Examination (MMSE) and Hamilton Depression Rating Scale (HAM-D) both at the time of admission and at discharge, an interval of approximately 3 months. This study examined the changes in both MMSE and HAM-D scores during the study period. A significant time-by-group interaction for results of the MMSE was observed, although there was no significant difference between the two groups on the HAM-D. Amelioration of cognitive impairment was greater in the milnacipran group than the control group. For PSD patients, milnacipran is effective in improving cognitive dysfunction.
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“Examples include outcomes reported as interaction statistics without data on within-group changes from baseline and between-group differences at study end24,27,51”
From Cognitive Effects of Pharmacotherapy for Major Depressive Disorder: A Systematic Review (2014) · cites this paper as [27]
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Cited by
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Cognitive Effects of Pharmacotherapy for Major Depressive Disorder: A Systematic Review
Keefe, R. S. E., McClintock, S. M., Roth, R. M., Doraiswamy, P. M., Tiger, S., & Madhoo, M. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08609 · Cited by 107
Metadata
- Authors
- SATO, S., YAMAKAWA, Y., TERASHIMA, Y., OHTA, H., & ASADA, T.
- Affiliations
- University of Tsukuba (JP)
- Ibaraki Prefectural University of Health Sciences (JP)
- Corresponding author
- SATO, SHINJI
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2006-09-06
- Volume
- 60
- Issue
- 5
- Pages
- 584-589
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1971336532
- Cited by
- 18
- References
- 0
- Citations by year
- 2025: 1 · 2020: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- milnacipran, post-stroke depression, cognitive impairment, serotonin-norepinephrine reuptake inhibitors, antidepressant efficacy, stroke, mood symptoms
- MeSH terms
- Milnacipran, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Cognition Disorders, Cyclopropanes, Depressive Disorder, Major, Major Depressive Disorder, Depressive Disorder, Female, Humans, Functional Laterality, Male, Middle Aged, Psychiatric Status Rating Scales, Tomography, X-Ray Computed, Mood Disorders, Stroke
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