Triglycerides + high‐density‐lipoprotein‐cholesterol dyslipidaemia, a coronary risk factor in elderly women: the CArdiovascular STudy in the ELderly
Abstract
Abstract Background: The relationship between serum triglycerides (TG) level and the risk of coronary heart disease (CHD) mortality remains controversial. Aims: To evaluate whether TG level is a risk factor for CHD in elderly people from general population, and to look for interactions between TG and other risk factors. Methods: 3257 subjects aged ≥ 65 years followed up for 12 years from the CArdiovascular STudy in the ELderly. Blood tests and anthropometric measurements were performed. Continuous items were divided into quintiles and, for each quintile, adjusted hazard ratio (HR) with 95% confidence interval (CI) for CHD mortality was derived by genders from Cox analysis. Results: In women, the HR of being in the fifth rather than in the first quintile of TG was 2.45 (CI 1.48−3.51). In turn, high‐density‐lipoprotein cholesterol (HDL‐C) inversely predicted CHD mortality; the HR of being in the first rather than in the fifth quintiles of HDL‐C was 1.52 (CI 1.24−2.36). The risk of CHD mortality further increased up to 3.81 (CI 1.62−5.43) when high TG and low HDL‐C were combined. No predictive role for either TG or HDL‐C was detected in men. Conclusions: TG and HDL‐C were independent predictors of CHD mortality in elderly women. The combination high TG + low HDL‐C quadrupled the risk of CHD mortality in this gender only. (Intern Med J 2005; 35: 604−610)
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In the Cardiovascular Study in the Elderly, women in the highest triglyceride quintile had a 2.5-fold greater risk of CVD mortality than women in the lowest quintile, even after adjustment for preexisting CVD, T2DM, obesity, and alcohol consumption.
“women in the highest triglyceride quintile had a 2.5-fold greater risk of CVD mortality than women in the lowest quintile, even after adjustment for preexisting CVD, T2DM, obesity, and alcohol consumption.”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [303]
When low HDL-C was also present, risk increased 3.8-fold.
“When low HDL-C was also present, risk increased 3.8-fold.”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [303]
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Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871 · see citing works
Schwartz, G. G., Abt, M., Bao, W., DeMicco, D., Kallend, D., Miller, M., Mundl, H., & Olsson, A. G. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.544 · Cited by 272 · see citing works
Cooney, M. T., Dudina, A., De Bacquer, D., Wilhelmsen, L., Sans, S., Menotti, A., De Backer, G., Jousilahti, P., Keil, U., Thomsen, T., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.041 · Cited by 250 · see citing works
Murad, M. H., Hazem, A., Coto-Yglesias, F., Dzyubak, S., Gupta, S., Bancos, I., Lane, M. A., Erwin, P. J., Berglund, L., Elraiyah, T., et al. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-2 · Cited by 87 · see citing works
- Authors
- Mazza, A., Tikhonoff, V., Schiavon, L., & Casiglia, E.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Mazza, A.
- Venue
- Internal Medicine Journal
- Publisher
- Wiley
- Published
- 2005-10
- Volume
- 35
- Issue
- 10
- Pages
- 604-610
- ISSN
- 1444-0903 (ISSN-L)
- 1445-5994
- OpenAlex
- W2019530645
- Cited by
- 53
- References
- 0
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Internal Medicine Journal (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- triglycerides, HDL cholesterol, dyslipidemia, coronary heart disease mortality, older women, cardiovascular risk factors, sex differences
- MeSH terms
- Aged, Coronary Disease, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Italy, Cholesterol, HDL, Population Surveillance, Prognosis, Risk Factors, Triglycerides, Hypertriglyceridemia, Survival Rate, Confidence Intervals, Proportional Hazards Models
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