The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis.
Open accessAbstract
BACKGROUND: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis. METHODS: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data. RESULTS: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant. CONCLUSIONS: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.
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Hypertriglyceridemia is associated with increased risk of cardiovascular events and pancreatitis.
“Lastly, a systematic review and meta-analysis of observational studies commissioned by The Endocrine Society found that hypertriglyceridemia is associated with increased risk of cardiovascular events and pancreatitis (14).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [14]
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Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887 · see citing works
“of cardiovascular events and pancreatitis (14).”
Self-citationPostprandial Hyperlipidemia and Remnant Lipoproteins
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- Authors
- Murad, M. H., Hazem, A., Coto-Yglesias, F., Dzyubak, S., Gupta, S., Bancos, I., Lane, M. A., Erwin, P. J., Berglund, L., Elraiyah, T., & Montori, V. M.
- Affiliations
- Mayo Clinic (US)
- VA Northern California Health Care System (US)
- Corresponding author
- Murad, M Hassan
- Venue
- BMC Endocrine Disorders
- Published
- 2012-03-31
- Volume
- 12
- Issue
- 1
- Pages
- 2-2
- ISSN
- 1472-6823 (ISSN-L)
- PMC
- PMC3342117
- OpenAlex
- W2158570675
- Cited by
- 87
- References
- 65
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 15 · 2013: 5 · 2012: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Endocrine Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- hypertriglyceridemia, cardiovascular events, cardiovascular mortality, myocardial infarction, acute pancreatitis, fasting triglycerides, dyslipidemia, cardiovascular risk
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