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Sarcopenia in the elderly: Basic and clinical issues
Abstract
The original definition of sarcopenia refers to the age‐related loss of muscle mass. The literature suggests that the prevalence of sarcopenia in 60‐ to 70‐year‐olds is in the range of 5–13%. Prevalence estimates increase to 11–50% for the population aged 80 years or older. Estimates by the World Health Organization suggest that there were 600 million people aged 60 years or older in the year 2000, and that this number will increase to 1.2 billion by the year 2025. There are, however, limited published data on serial measures of muscle mass in older subjects to establish the age‐related changes in muscle mass and to relate this change with adverse health consequences. This review is focused on the definition, prevalence, symptoms, pharmacy and physical therapy of sarcopenia in older subjects with the aim of promoting the recognition and treatment of age‐related sarcopenia in the clinical setting. Geriatr Gerontol Int 2012; 12: 388–396.
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“Other hormones, including insulin-like growth factors-1 (IGF-1), growth hormone, testosterone, and estrogen, also regulate the anabolic and catabolic progressions in muscle (46, 47).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [46]
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Metadata
- Authors
- Wang, C., & Bai, L.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Bai, Li
- ORCID
- Wang, Cuiying
- Venue
- Geriatrics & Gerontology International
- Publisher
- Wiley
- Published
- 2012-04-25
- Volume
- 12
- Issue
- 3
- Pages
- 388-396
- ISSN
- 1444-1586 (ISSN-L)
- 1447-0594
- OpenAlex
- W1533361714
- Semantic Scholar
- b20f29c3f11a39492de696cafc8eafcce9d8ba9e
- Cited by
- 170
- References
- 92
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 14 · 2023: 20 · 2022: 16 · 2021: 9 · 2020: 9 · 2019: 17 · 2018: 10 · 2017: 13 · 2016: 10 · 2015: 9 · 2014: 9 · 2013: 16 · 2012: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Geriatrics and gerontology international/Geriatrics & gerontology international (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- sarcopenia, older adults, prevalence, clinical symptoms, pharmacotherapy, physiotherapy
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Prevalence, Physical Therapy Modalities, Sarcopenia
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