Characterization of placental transfer of polychlorinated dibenzo‐p‐dioxins, dibenzofurans and polychlorinated biphenyls in normal pregnancy
Abstract
Aim: Prenatal exposure to dioxins may result in many adverse health effects. However, the mechanisms by which dioxins are transferred from mother to fetus through the placenta are not well understood. The aim of this study was to investigate the differences in dioxin concentrations between maternal blood, the placenta, and cord blood in normal pregnant women, and to identify which individual congeners of these compounds are transferred from mother to fetus through the placenta. Material and Methods: Samples were collected from 19 pregnant Japanese women. Specific congeners of seven polychlorinated dibenzo‐p‐dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs), and four non‐ortho polychlorinated biphenyls (PCBs) were analyzed. Results: The TEQ concentrations of PCDDs, PCDFs, and non‐ortho PCBs were 8.03, 3.39, and 3.95 pg TEQ/g lipid, respectively, in the maternal blood; 8.78, 3.61, and 0.87 pg TEQ/g lipid in the placenta; and 4.33, 1.25, 1.08 pg TEQ/g lipid in the cord blood. Among specific congeners, 1,2,3,7,8‐PentaCDD and 2,3,4,7,8‐PentaCDF exhibited a placenta to maternal blood ratio greater than 1.0, while OctaCDD exhibited the greatest cord blood to placenta ratio. The cord blood to maternal blood ratio of total PCDDs was significantly higher than that of total PCDFs and total non‐ortho PCBs. Conclusion: The dioxin concentration in cord blood was approximately half of the amount in maternal blood, despite congeners showing a high toxic equivalency factor accumulating in the placenta. PCDDs were transferred more readily than PCDFs and non‐ortho PCBs from maternal blood to the fetus through the placenta.
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Levels of dioxins in the fetal circulation were found to be approximately half those in the mother.
“Other studies have compared maternal and fetal blood levels at the time of delivery; for example, levels of dioxins in the fetal circulation were found to be approximately half those in the mother (536).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [536]
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
- Authors
- Tsukimori, K., Morokuma, S., Hori, T., Takahashi, K., Hirata, T., Otera, Y., Fukushima, K., Kawamoto, T., & Wake, N.
- Affiliations
- Kyushu University (JP)
- Fukuoka Institute of Health and Environmental Sciences (JP)
- University of Occupational and Environmental Health Japan (JP)
- Corresponding author
- Tsukimori, Kiyomi
- Venue
- Journal of Obstetrics and Gynaecology Research
- Publisher
- Wiley
- Published
- 2012-06-04
- Volume
- 39
- Issue
- 1
- Pages
- 83-90
- ISSN
- 1341-8076 (ISSN-L)
- 1447-0756
- OpenAlex
- W1921400481
- Cited by
- 39
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 9 · 2013: 4 · 2012: 1
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of obstetrics and gynaecology research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22510036)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Keywords
- placental transfer, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, maternal blood, umbilical cord blood, placenta, toxic equivalent quantity, congeners, normal pregnancy
- MeSH terms
- Polychlorinated Dibenzodioxins, Adult, Benzofurans, Female, Fetal Blood, Humans, Japan, Maternal-Fetal Exchange, Polychlorinated Biphenyls, Pregnancy
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