Long‐term Potentiation and Field EPSPs in the Lateral and Medial Perforant Paths in the Dentate Gyrus In Vitro: a Comparison
Abstract
The entorhinal cortex projects monosynaptically to the granule cells in the dentate gyrus via the lateral and medial perforant paths. These two subdivisions of the perforant path differ with respect to synaptic properties, and recent studies suggest that they also differ with respect to long-term potentiation (LTP). In the present study, using the in vitro slice preparation of the guinea-pig hippocampus, field excitatory postsynaptic potentials (EPSPs) and LTP in the lateral and medial perforant paths were compared. The two pathways were distinguished on the basis of their different termination in the dendritic layer, their different pharmacology and short-term synaptic facilitation. The field EPSP [obtained in the presence of gamma-aminobutyric acid (GABA) A and B receptor antagonists] consisted of a non-N-methyl-d-aspartate (NMDA) component with different time characteristics in the two pathways, the decay being monoexponential in the lateral perforant path and biexponential in the medial one. In addition, the field EPSP in both pathways contained a small NMDA-mediated component that could also be observed after complete blockade of the non-NMDA one. LTP induction in both lateral and medial perforant paths was facilitated by blockade of GABAA inhibition, showed associative properties, and was blocked by NMDA receptor antagonists. Following the induction event, LTP in both pathways developed to a peak value within 30 - 40 s, and the stability of LTP was correlated with the a…
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Application of NMDAR antagonists such as AP5 completely blocks the induction of LTP in most hippocampal synapses.
“For instance, application of NMDAR antagonists (such as 2-amino-5-phosphonopropionic acid [AP5]) completely blocks the induction of LTP in most hippocampal synapses (Collingridge et al., 1983; Zalutsky and Nicoll, 1990; Hanse and Gustafsson, 1992).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Hanse and Gustafsson, 1992
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The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
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Electrophysiological identification of medial and lateral perforant path inputs to the dentate gyrus
Petersen, R. P., Moradpour, F., Eadie, B. D., Shin, J. D., Kannangara, T. S., Delaney, K. R., & Christie, B. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.063 · Cited by 65 · see citing works
- Authors
- Hanse, E., & Gustafsson, B.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Hanse, Eric
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1992-11
- Volume
- 4
- Issue
- 11
- Pages
- 1191-1201
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1978442737
- Cited by
- 89
- References
- 1
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2020: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, perforant path, lateral perforant path, medial perforant path, dentate gyrus, field excitatory postsynaptic potentials, entorhinal cortex, granule cells, NMDA receptor, non-NMDA receptors, GABAA inhibition, synaptic facilitation
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