Cited by 232Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

Nosten-Bertrand, M., Errington, M. L., Murphy, K. P. S. J., Tokugawa, Y., Barboni, E., Kozlova, E., Michalovich, D., Morris, R. G. M. +4 more·1996·Nature

Abstract

The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.

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Crossref · 10.1038/379826a0

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Authors
Nosten-Bertrand, M., Errington, M. L., Murphy, K. P. S. J., Tokugawa, Y., Barboni, E., Kozlova, E., Michalovich, D., Morris, R. G. M., Silver, J., Stewart, C. L., Bliss, T. V. P., & Morris, R. J.
Affiliations
  • National Institute for Medical Research (GB)
  • Cornell University (US)
  • Erasmus University Rotterdam (NL)
Venue
Nature
Published
1996-02
Volume
379
Issue
6568
Pages
826-829
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2089087278
Cited by
232
References
29
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 7
FWCI
10.30
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
CD90, long-term potentiation, spatial learning, hippocampus, dentate gyrus, CA1, adhesion molecules, synaptic plasticity, knockout mice, water maze
MeSH terms
Animals, Female, gamma-Aminobutyric Acid, Hippocampus, Male, Mice, Inbred C57BL, Long-Term Potentiation, Gene Targeting, Maze Learning, Thy-1 Antigens, Dentate Gyrus, Mice

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