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5‐HT 2A and α1b‐adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants
Abstract
Addictive properties of drugs of misuse are generally considered to be mediated by an increased release of dopamine (DA) in the ventral striatum. However, recent experiments indicated an implication of alpha1b-adrenergic receptors in behavioural responses to psychostimulants and opiates. We show now that DA release induced in the ventral striatum by morphine (20 mg/kg) is completely blocked by prazosin (1 mg/kg), an alpha1-adrenergic antagonist. However, morphine-induced increases in DA release in the ventral striatum were found to be similar in mice deleted for the alpha1b-adrenergic receptor (alpha1b-AR KO) and in wild-type (WT) mice, suggesting the presence of a compensatory mechanism. This acute morphine-evoked DA release was completely blocked in alpha1b-AR KO mice by SR46349B (1 mg/kg), a 5-HT2A antagonist. SR46349B also completely blocked, in alpha1b-AR KO mice, the locomotor response and the development of behavioural sensitization to morphine (20 mg/kg) and D-amphetamine (2 mg/kg). Accordingly, the concomitant blockade of 5-HT2A and alpha1b-adrenergic receptors in WT mice entirely blocked acute locomotor responses but also the development of behavioural sensitization to morphine, D-amphetamine or cocaine (10 mg/kg). We observed, nevertheless, that inhibitory effects of each antagonist on locomotor responses to morphine or D-amphetamine were more than additive (160%) in naïve WT mice but not in those sensitized to either drug. Because of these latter data and the possible compensation by 5-HT2A receptors for the genetic deletion of alpha1b-adrenergic receptors, we postulate the existence of a functional link between these receptors, which vanishes during the development of behavioural sensitization.
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“MDMA also strongly affects 5-HT2A receptors, which are important mediators of behavioral sensitization (47–49).”
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Metadata
- Authors
- Auclair, A., Drouin, C., Cotecchia, S., Glowinski, J., & Tassin, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Tassin, Jean‐Pol
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 20
- Issue
- 11
- Pages
- 3073-3084
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2007935614
- Semantic Scholar
- 6e7f99f756cb4e158e01c8c27ae8be88a5eaa920
- Cited by
- 163
- References
- 63
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 5 · 2016: 10 · 2015: 3 · 2014: 11 · 2013: 3 · 2012: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Servier
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- 5-HT2A receptor, alpha1B-adrenergic receptor, dopamine release, ventral striatum, morphine, prazosin, behavioral sensitization, locomotor response, psychostimulants, cocaine, amphetamine, receptor interaction, compensatory mechanisms
- MeSH terms
- Adrenergic alpha-Antagonists, Central Nervous System Stimulants, Anesthetics, Local, Animals, Behavior, Animal, Brain Chemistry, Cocaine, Corpus Striatum, Dextroamphetamine, Dopamine, Drug Administration Schedule, Drug Interactions, Fluorobenzenes, Male, Motor Activity, Narcotics, Phenols, Prazosin, Serotonin Antagonists, Time Factors, Microdialysis, Receptors, Adrenergic, alpha-1, Mice, Knockout, Receptor, Serotonin, 5-HT2A, Mice
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