Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

Sesack, Susan R.; Pickel, Virginia M.

doi:10.1002/cne.903200202

Cited by 820Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

Sesack, Susan R., Pickel, Virginia M.·1992·Journal of Comparative Neurology

DOI 10.1002/cne.903200202

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Abstract

Physiological and pharmacological studies indicate that descending projections from the prefrontal cortex modulate dopaminergic transmission in the nucleus accumbens septi and ventral tegmental area. We investigated the ultrastructural bases for these interactions in rat by examining the synaptic associations between prefrontal cortical terminals labeled with anterograde markers (lesion‐induced degeneration or transport of Phaseolus vulgaris leucoagglutinin; PHA‐L) and neuronal processes containing immunoreactivity for the catecholamine synthesizing enzyme, tryosine hydroxylase. Prefrontal cortical terminals in the nucleus accumbens and ventral tegmental area contained clear, round vesicles and formed primarily asymmetric synapses on spines or small dendrites. In the ventral tegmental area, these terminals also formed asymmetric synapses on large dendrites and a few symmetric axodendritic synapses. In the nucleus accumbens septi , degenerating prefrontal cortical terminals synapsed on spiny dendrites which received convergent input from terminals containing peroxidase immunoreactivity for tyrosine hydroxylase, or from unlabeled terminals. In single sections, some tyrosine hydroxylase‐labeled terminals formed thin and punctate symmetric synapses with dendritic shafts, or the heads and necks of spines. Close appositions, but not axo‐axonic synapses, were frequently observed between degenerating prefrontal cortical afferents and tyrosine hydroxylase‐labeled or unlabeled terminals. In the ventral tegmental area , prefrontal cortical terminals labeled with immunoperoxidase for PHA‐L were in synaptic contact with dendrites containing immunogold reaction product for tyrosine hydroxylase, or with unlabeled dendrites. These results suggest that: (1) catecholaminergic (mainly dopaminergic) and prefrontal cortical terminals in the nucleus accumbens septi dually synapse on common spiny neurons; and (2) dopaminergic neurons in the ventral tegmental area receive monosynaptic input from prefrontal cortical afferents. This study provides the first ultrastructural basis for multiple sites of cellular interaction between prefrontal cortical efferents and mesolimbic dopaminergic neurons.

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The PFC sends out glutamatergic afferents to the VTA as well as to the nucleus accumbens, modulating dopaminergic signaling.
“The PFC furthermore sends out glutamatergic afferents to the VTA as well as to the nucleus accumbens modulating dopaminergic signaling [204–206].”
From Development of prefrontal cortex (2022) · cites this paper as [204]
Descending projections from the PFC provide an inhibitory influence over lower brain structures involved in emotionality, such as the amygdala, dorsal raphe, and hypothalamus.
“Descending projections from the PFC appear to provide an inhibitory influence over lower brain structures involved in emotionality, such as the amygdala, dorsal raphe and hypothalamus (Arnsten and Goldman-Rakic [428]; Sesack and Pickel [429]; Rempel-Clower and Barbas [430]; Hajós et al. [431]; Quirk and Gehlert [432]; Quirk et al. [433]; Milad et al. [434]; Likhtik et al. [379]; Amat et al. [388”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Sesack and Pickel [429]

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Authors: Sesack, S. R., & Pickel, V. M.
Affiliations: University of Pittsburgh (US)
Cornell University (US)
Corresponding author: Sesack, Susan R.
ORCID: Sesack, Susan R.
Pickel, Virginia M.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1992-06-08
Volume: 320
Issue: 2
Pages: 145-160
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903200202
OpenAlex: W1965792012
Cited by: 820
References: 70
Citations by year: 2026: 3 · 2025: 1 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 18 · 2015: 22 · 2014: 20 · 2013: 25 · 2012: 36
FWCI: 5.98
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4506 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2f32ns008193-03)
National Institute of Mental Health (MH-40342)
National Institute of Neurological Disorders and Stroke (NS08193)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: prefrontal cortex, nucleus accumbens septi, ventral tegmental area, dopaminergic neurons, synaptic ultrastructure, asymmetric synapses, axodendritic synapses, tyrosine hydroxylase, monosynaptic input, mesolimbic system, dendritic spines, axo-axonic synapses
MeSH terms: Animals, Catecholamines, Cerebral Cortex, Dopamine, Frontal Lobe, Histocytochemistry, Limbic System, Male, Microscopy, Electron, Nerve Endings, Neurons, Neurons, Efferent, Nucleus Accumbens, Phytohemagglutinins, Rats, Inbred Strains, Staining and Labeling, Synapses, Tegmentum Mesencephali, Tyrosine 3-Monooxygenase, Rats

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Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

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