Physiological markers of local sleep
Open accessAbstract
Substantial evidence suggests that brain regions that have been disproportionately used during waking will require a greater intensity and/or duration of subsequent sleep. For example, rats use their whiskers in the dark and their eyes during the light, and this is manifested as a greater magnitude of electroencephalogram (EEG) slow-wave activity in the somatosensory and visual cortex during sleep in the corresponding light and dark periods respectively. The parsimonious interpretation of such findings is that sleep is distributed across local brain regions and is use-dependent. The fundamental properties of sleep can also be experimentally defined locally at the level of small neural assemblies such as cortical columns. In this view, sleep is orchestrated, but not fundamentally driven, by central mechanisms. We explore two physiological markers of local, use-dependent sleep, namely, an electrical marker apparent as a change in the size and shape of an electrical evoked response, and a metabolic marker evident as an evoked change in blood volume and oxygenation delivered to activated tissue. Both markers, applied to cortical columns, provide a means to investigate physiological mechanisms for the distributed homeostatic regulation of sleep, and may yield new insights into the consequences of sleep loss and sleep pathologies on waking brain function.
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SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures.
“these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [975]
“Mechanisms of Sleep Regulation” reports use-dependent local increases in SWA. “Defining what sleeps” also says subcortical structures may influence and time whole-animal sleep, but the copy does not establish global regulation of SWA by brain-stem and diencephalic structures specifically. Pages are not available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredEncoding of information during waking enhances subsequent SWA in specific brain regions.
“in demonstrating that the encoding of information during waking enhances subsequent SWA in specific brain regions, these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [975]
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“cortex of rats during the dark period when they use their whiskers more, and greater in the visual cortex during the light period when they use their eyes more (Yasuda et al., 2005).”
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- Authors
- Rector, D. M., Schei, J. L., Van Dongen, H. P. A., Belenky, G., & Krueger, J. M.
- Affiliations
- Washington State University Spokane (US)
- ORCID
- Belenky, Gregory
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 29
- Issue
- 9
- Pages
- 1771-1778
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2688439
- OpenAlex
- W2102607756
- Cited by
- 104
- References
- 3
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 13 · 2012: 11
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH060263, MH-60263, MH71830, R01MH071830)
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS025378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- local sleep, sleep homeostasis, cortical columns, blood volume, cerebral oxygenation, slow-wave activity, sleep deprivation, sleep pathology
- MeSH terms
- Animals, Blood Volume, Brain, Cerebrovascular Circulation, Evoked Potentials, Humans, Neural Pathways, Oxygen, Sleep
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