The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
Abstract
Circadian rhythms are an essential property of many living organisms, and arise from an internal pacemaker, or clock. In mammals, this clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus, and generates an intrinsic circadian rhythm that is transmitted to other parts of the CNS. We will review the evidence that basic adaptive functions of the circadian system rely on functional plasticity in the neuronal network organization, and involve a change in phase relation among oscillatory neurons. We will illustrate this for: (i) photic entrainment of the circadian clock to the light–dark cycle; and (ii) seasonal adaptation of the clock to changes in day length. Molecular studies have shown plasticity in the phase relation between the ventral and dorsal SCN during adjustment to a shifted environmental cycle. Seasonal adaptation relies predominantly on plasticity in the phase relation between the rostral and caudal SCN. Electrical activity is integrated in the SCN, and appears to reflect the sum of the differently phased molecular expression patterns. While both photic entrainment and seasonal adaptation arise from a redistribution of SCN oscillatory activity patterns, different neuronal coupling mechanisms are employed, which are reviewed in the present paper.
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“Pacemaker cells, which individually generate circadian rhythms in the suprachiasmatic nucleus of the hypothalamus, are organized in separate networks16.”
From Bipolar mood cycles associated with lunar entrainment of a circadian rhythm (2018) · cites this paper as [16]
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“Over the past several decades, it has gradually been discovered that these changes in human body are controlled by specific brain circuits and neurotransmitters (Meijer et al., 2010).”
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“The environmental cues, particularly food, light, and temperature, exert profound effects on circadian genes regulation (Magnone et al. 2005; Malatesta et al. 2007; Pan and Hus-sain 2009; Meijer et al. 2010).”
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“Mice and rats exposed to longer or variable day lengths, for example, exhibit delayed external markers of pubertal onset(Lafaille et al., 2015), more variable activity rhythms(Kim and Harrington, 2008; Meijer et al., 2010), and have altered weight gain trajectories(Brown-Douglas et al., 2004).”
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“Experimental studies have shown that SCN subregions can maintain distinct circadian phases, with phase differences approaching 8–10 hours [12,13].”
Atkinson, L. (2014) · Kent Academic Repository (University of Kent)
Metadata
- Authors
- Meijer, J. H., Michel, S., VanderLeest, H. T., & Rohling, J. H. T.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Meijer, Johanna H.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2010-12
- Volume
- 32
- Issue
- 12
- Pages
- 2143-2151
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2157329350
- Semantic Scholar
- e6ae1ddf69a540699da985faa18f4dd0e558d367
- Cited by
- 119
- References
- 106
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 8 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, suprachiasmatic nucleus, neuroplasticity, light entrainment, seasonal adaptation, day length, neuronal coupling, circadian rhythm
- MeSH terms
- Adaptation, Physiological, Animals, Circadian Rhythm, Nerve Net, Neuronal Plasticity, Seasons, Suprachiasmatic Nucleus, Photoperiod, Neurotransmitter Agents, Jet Lag Syndrome, Circadian Clocks
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