The DOI matches its Crossref record; 82 of the 83 references it cites were found in a registry or an index.
Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre‐exposure
Open accessAbstract
Stressors can exert a wide variety of responses, ranging from adaptive responses to pathological changes; moreover, recent studies suggest that mild stressors can attenuate the response of a system to major stressful events. We have previously shown that 2‐week exposure to cold, a comparatively mild inescapable stressor, induced a pronounced reduction in ventral tegmental area (VTA) dopamine (DA) neuron activity, whereas restraint stress increases DA neuron activity. However, it is not known if these stressors differentially impact the VTA in a region‐specific manner, if they differentially impact behavioral responses, or whether the effects of such different stressors are additive or antagonistic with regard to their impact on DA neuron firing. To address these questions, single‐unit extracellular recordings were performed in anesthetized control rats and rats exposed to chronic cold, and tested after delivery of a 2‐h restraint session. Chronic cold stress strongly attenuated the number of DA neurons firing in the VTA, and this effect occurred primarily in the medial and central VTA regions that preferentially project to reward‐related ventral striatal regions. Chronic cold exposure also prevented the pronounced increase in DA neuron population activity without affecting the behavioral sensitization to amphetamine produced by restraint stress. Taken together, these data show that a prolonged inescapable mild stressor can induce plastic changes that attenuate the DA system response to acute stress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“chronic mild or chronic cold stress instead reduce VTA population activity [50, 51].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Kalivas, P., & Stewart, J. (1991) · Brain research. Brain research reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,087
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Self-citationAbercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106
Flagged first, then by citations
1 of the 83 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Chang C.H., 2011, Beta noradrenergic receptors modulate acute restraint‐mediated down‐regulation of dopamine system activity, Soc. Neurosci.
- Willner P., 1995, Psychopharmacology: The Fourth Generation of Progress, 921
Cited by
Sorted by citations
Items 101–130 of 130
Grace, A. A., & Uliana, D. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03513-7 · Cited by 5
Self-citationPrefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression
Uliana, D. L., & Grace, A. A. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70409 · Cited by 8
Self-citationAcute stress induces long-lasting alterations in the dopaminergic system of female micePreprint
Wichmann, R., Weele, C. M. V., Yosafat, A. S., Schut, E. H. S., Verharen, J. P. H., Sridharma, S., Siciliano, C. A., Izadmehr, E. M., Farris, K. M., Wildes, C. P., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/168492 · Cited by 6
Optogenetics: illuminating the neural bases of rodent behavior
Lobo, M. K., Francis, C., & Chaudhury, D. (2014) · Open Access Animal Physiology · doi:10.2147/oaap.s42339 · Cited by 6
14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia
Antunes, A. S. L. M., Saia-Cereda, V. M., Crunfli, F., & Martins‐de‐Souza, D. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1925585 · Cited by 5
Psychotic Features Abated with Vitamin D Treatment in a Patient with Major Depressive Disorder
Fipps, D. C., & Rainey, E. (2020) · Case Reports in Psychiatry · doi:10.1155/2020/2046403 · Cited by 5
Harris, J. C., Liuzzi, M. T., Malames, B. A., Larson, C., & Lisdahl, K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1237163 · Cited by 2
Dépression et régulation de l’activité dopaminergique
Vialou, V. (2013) · médecine/sciences · doi:10.1051/medsci/2013295010 · Cited by 5
Charmchi, E., Faramarzi, G., Rashvand, M., Zendehdel, M., & Haghparast, A. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03199-5 · Cited by 4
Rybka, K. A., Lafrican, J. J., Meunier, P., Reilly, D. M., Parra, K. E., Colón, L. M., Poulos, A. M., & Zuloaga, D. G. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107554 · Cited by 3
Karaoglan, M., & Grace, A. A. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116283 · Cited by 3
Self-citationOptogenetics: Illuminating the Neural Circuits of Depression
Muir, J., & Bagot, R. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00014-7 · Cited by 3
Feng, X., Ye, Z., Xie, K., Zhu, S., Wu, X., Sun, Z., Feng, X., Mo, Y., Liang, J., Shu, G., et al. (2024) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2024.103959 · Cited by 2
Activation of 5-HT4 receptors reverses stress-induced dopamine system dysregulation
Yang, O. J., Perez, S. M., & Lodge, D. J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110810 · Cited by 2
Valenti, O., Mueller, K., Yang, J., Bulut, H., Rekawek, K. A., & Boehm, S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111609 · Cited by 2
Self-citationRegulation and Modulation of Depression-Related Behaviours: Role of Dopaminergic Neurons
Radwan, B., Liu, H., & Chaudhury, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-46437-4_8 · Cited by 2
From memory disorders to the development of depression: A system approach
Grigoryan, G. A. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105440 · Cited by 1
Mohammed, Z., Haruna, Z. K., Abdullahi, Z. I., Hussein, S. A., Kurfi, B. G., Habila, J. D., Abdullahi, M., Aliyu, A. B., & Ibrahim, A. A. E.-M. (2020) · Bayero Journal of Pure and Applied Sciences · doi:10.4314/bajopas.v12i1.29s · Cited by 1
The Role of Dopamine in Schizophrenia, Depression, and Addiction
杨, 成. (2023) · Advances in Social Sciences · doi:10.12677/ass.2023.124230 · Cited by 1
Glucocorticoid modulation of the mesocortical dopamine system and aspects of executive function
Butts, K. A. (2013) · cIRcle (University of British Columbia) · doi:10.14288/1.0073693
Understanding Mood Disorders Using Electrophysiology and Circuit Breaking
Liu, H., & Chaudhury, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-57363-2_14
Zimmerman, E. I. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
C-12-10 学習機能を実現する連想メモリのLSI設計(C-12.集積回路B(ディジタル),一般講演)
榊原, 尚., Ahmadi, A., Abedin, M. A., 田中, 裕., Mattausch, H. J., & 小出, 哲. (2007) · 電子情報通信学会総合大会講演論文集
Шкет, А. П., Шумовец, В. В., Spiridonov, S. V., Геннадьевна, Ш. Л., Иосифович, К. Д., Викторовна, К. А., Токунов, В. А., Петрович, О. Ю., Komarovskii, A. A., Одинцов, В. О., et al. (2013) · Medical Almanac
Sheikh, S., Rehman, M. M. U., Emad, S., Sarfaraz, Y., Sadaf, S., Batool, Z., Yousuf, S., Qadeer, S., & Perveen, T. (2023) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps.2023.36.1.sp.239-245.1
Narain, P., Petković, A., Šušić, M., Haniffa, S., Drou, N., Arnoux, M., Anwar, M., & Chaudhury, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.05.556324
Yang, L., Yu, X., Yang, Q., Zhu, G., Xu, W., Yu, S., Zhang, R., Lin, L., Yu, L., Li, M., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124252
Gündoğdu, E. D., & ÖZAÇMAK, H. S. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150512
Luckett, C. (2022) · Digital Archive @ GSU · doi:10.57709/5670102
Metadata
- Authors
- Valenti, O., Gill, K. M., & Grace, A. A.
- Affiliations
- University of Pittsburgh (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2012-04
- Volume
- 35
- Issue
- 8
- Pages
- 1312-1321
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC3335739
- OpenAlex
- W2104293622
- Cited by
- 131
- References
- 83
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH057440)
- National Institute on Drug Abuse (DA 15408, R56DA015408, R01DA015408)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesolimbic dopamine system, ventral tegmental area, chronic cold stress, restraint stress, stress adaptation, amphetamine sensitization, ventral striatum, single-unit recording, stressor specificity
- MeSH terms
- Action Potentials, Afferent Pathways, Amphetamine, Analysis of Variance, Animals, Cold Temperature, Disease Models, Animal, Male, Motor Activity, Neural Inhibition, Restraint, Physical, Stress, Psychological, Time Factors, Dopamine Agents, Rats, Sprague-Dawley, Prefrontal Cortex, Ventral Tegmental Area, Rats, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
