The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
Open accessAbstract
A marquee feature of the powerful human pathogen Mycobacterium tuberculosis is its macrophage parasitism. The intracellular survival of this microorganism rests upon its ability to arrest phagolysosome biogenesis, avoid direct cidal mechanisms in macrophages, and block efficient antigen processing and presentation. Mycobacteria prevent Rab conversion on their phagosomes and elaborate glycolipid and protein trafficking toxins that interfere with Rab effectors and regulation of specific organellar biogenesis in mammalian cells. One of the major Rab effectors affected in this process is the type III phosphatidylinositol 3-kinase hVPS34 and its enzymatic product phosphatidylinositol 3-phosphate (PI3P), a regulatory lipid earmarking organellar membranes for specific trafficking events. PI3P is also critical for the process of autophagy, recently recognized as an effector of innate and adaptive immunity. Induction of autophagy by physiological, pharmacological or immunological signals, including the major antituberculosis Th1 cytokine IFN-gamma and its downstream effector p47 GTPase LRG-47, can overcome mycobacterial phagosome maturation block and inhibit intracellular M. tuberculosis survival. This review summarizes the findings centred around the PI3P-nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect.
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Cites
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Self-citationSturgill-Koszycki, S., Schlesinger, P. H., Chakraborty, P., Haddix, P. L., Collins, H. L., Fok, A. K., Allen, R. D., Gluck, S. L., Heuser, J., & Russell, D. G. (1994) · Science · doi:10.1126/science.8303277 · Cited by 1,302
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860 · cited 3×
“…is more than just an innate defence mechanism and its role in adaptive immunity enabling antigen processing for MHC II presen- © 2006 The Authors Journal compilation © 2006 Blackwell Publishing Ltd, Cellular Microbiology, 8, 719–727 tation has only begun to be appreciated (Paludan et al., 2005).”
BackgroundImmune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · cited 1×
“…to killing of mycobacteria by a trafficking-independent mechanism, but involves an active membrane sorting mechanism dependent on LRG-47, a member of the family of 47 kDa GTPases inducible by interferon-γ (MacMicking et al., 2003) (LRG-47 mode of action will be covered in the context of autophagy).”
BackgroundEssential Role for Cholesterol in Entry of Mycobacteria into Macrophages
Gatfield, J., & Pieters, J. (2000) · Science · doi:10.1126/science.288.5471.1647 · Cited by 615
Granelli-Piperno, A., Pritsker, A., Pack, M., Shimeliovich, I., Arrighi, J.-F., Park, C. G., Trumpfheller, C., Piguet, V., Moran, T. M., & Steinman, R. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4265 · Cited by 208
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Cited by
Tanida, I., Ueno, T., & Kominami, E. (2008) · Methods in Molecular Biology™ · doi:10.1007/978-1-59745-157-4_4 · Cited by 1,785
Toll‐like receptors control autophagy
Delgado, M. A., Elmaoued, R. A., Davis, A. S., Kyei, G., & Deretic, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.31 · Cited by 744
Self-citationAutophagy: Basic Principles and Relevance to Disease
Kundu, M., & Thompson, C. B. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.091842 · Cited by 523
Listeria monocytogenes ActA-mediated escape from autophagic recognition
Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1967 · Cited by 448
ESX secretion systems: mycobacterial evolution to counter host immunity
Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382
Metadata
- Authors
- Deretic, V., Singh, S., Master, S., Harris, J., Roberts, E., Kyei, G., Davis, A., de Haro, S., Naylor, J., Lee, H.-H., & Vergne, I.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2006-05
- Volume
- 8
- Issue
- 5
- Pages
- 719-727
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2090941537
- Cited by
- 311
- References
- 7
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deretic, V., Singh, S., Master, S., Harris, J., Roberts, E., Kyei, G., Davis, A., de Haro, S., Naylor, J., Lee, H.-H., & Vergne, I. (2006). Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2006.00705.x
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