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Microalbuminuria Predicts Mortality in Noninsulin‐dependent Diabetes
Abstract
Forty‐four non‐insulin‐dependent diabetics (NIDD), all with urine negative to Albustix, were studied in 1966/67. By the end of 1980, 17 had died, all but two from cardiovascular causes. All causes of mortality and time to death were significantly related in univariate analyses to age and to the overnight urinary albumin excretion rate (AER), but not to systolic and diastolic blood pressure levels or to duration of diabetes when the latter was corrected for age. Age and duration were highly correlated with each other. In multivariate analyses age and AER were independent predictors of both mortality and time to death, with AER having the greater degree of significance. Thus subclinically elevated albumin excretion rates (‘microalbuminuria’) indicate a substantially increased mortality risk in non‐insulin‐dependent diabetes.
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Cited by
Albuminuria reflects widespread vascular damage: The Steno hypothesis
Deckert, T., Feldt-Rasmussen, B., Borch-Johnsen, K., Jensen, T., & Kofoed-Enevoldsen, A. (1989) · Diabetologia · doi:10.1007/bf00285287 · Cited by 1,400
Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
Barnett, A. H., Bain, S. C., Bouter, P., Karlberg, B., Madsbad, S., Jervell, J., & Mustonen, J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042274 · Cited by 910
Keane, W. F., Brenner, B. M., de Zeeuw, D., Grunfeld, J.-P., McGill, J., Mitch, W. E., Ribeiro, A. B., Shahinfar, S., Simpson, R. L., Snapinn, S. M., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00885.x · Cited by 539
Vaur, L., Gueret, P., Lievre, M., Chabaud, S., Passa, P., & For the DIABHYCAR Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.3.855 · Cited by 163
Teixeira, S. R., Tappenden, K. A., Carson, L., Erdman, J. W., Jones, R., Prabhudesai, M., & Marshall, W. P. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.8.1874 · Cited by 157
Collins, A. C. G., Sethi, M., MacDonald, F. A., Brown, D., & Viberti, G. C. (1993) · Diabetologia · doi:10.1007/bf02374489 · Cited by 57
Self-citationCost-effectiveness of two screening programs for microalbuminuria in type 2 diabetes
Lepore, G., Maglio, M. L., Nosari, I., Dodesini, A. R., & Trevisan, R. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2103 · Cited by 26
Gimeno Orna, J. A., Boned Juliani, B., Lou Arnal, L. M., & Castro Alonso, F. J. (2003) · Revista Clínica Española · doi:10.1016/s0014-2565(03)71346-0 · Cited by 13
Metadata
- Authors
- Jarrett, R. J., Viberti, G. C., Argyropoulos, A., Hill, R. D., Mahmud, U., & Murrells, T. J.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 1984-05
- Volume
- 1
- Issue
- 1
- Pages
- 17-19
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1991402756
- Cited by
- 511
- References
- 1
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- closed
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