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Cited by 4Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Differential Metabolic Actions of Biosynthetic Insulin Analogues in Normal Man Assessed by Stable Isotopic Tracers

Gelding, S. V., Coldham, N., Anyaoku, V., Heslop, K., Halliday, D., Johnston, D. G.·1993·Diabetic Medicine
DOI 10.1111/j.1464-5491.1993.tb00101.x
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Abstract

Insulin analogues have been produced with high affinity for the insulin receptor and with affinity lower than that of native insulin, but differences in activity when administered in vivo to man are unconvincing. We have used very low dose insulin (0.005 units kg−1 h−1) to investigate possible differences in effect of these insulin analogues on lipolysis in seven healthy subjects. Only minor effects on blood glucose concentration were observed and glucose turnover measured isotopically with 6,6 2 H glucose and leucine turnover measured with 1−13 C leucine did not change significantly. Fatty acid levels decreased with insulin (area under curve, median (range) −23 (‐41–10) mmol l−1 h) and with the low affinity analogue (‐28 (‐42–19) mmol l−1 h), but the high affinity analogue had no significant effect compared with controls (high affinity analogue −8 (‐28–35) mmol l−1 h; control +15 (11–53) mmol l−1 h). Glycerol production measured isotopically decreased with insulin (‐0.54 (‐1.50–0.63) μmol kg−1 min−1) and with the low affinity analogue (‐0.74 (‐1.76–0.72) μmol kg−1 min−1), but the high affinity analogue at these doses had no significant effect on glycerol turnover (‐0.19 (‐0.74–1.13) μmol kg−1 min−1). Thus at these low infusion rates insulin itself and the low affinity analogue suppressed lipolysis, as assessed by glycerol turnover and by circulating fatty acid concentrations. The high affinity analogue was cleared rapidly from the circulation producing no measurable increase in immunoreactive insulin concentrations, and no effect was observed on lipolysis.

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Crossref · 10.1111/j.1464-5491.1993.tb00101.x

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Citations

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Research works printed but not linked: 7

  1. Vølund A., 1988, Insulin analogs with altered absorption kinetics exhibit metabolic effects similar to native insulin, Diabetes Res Clin Prac, 5, S369
  2. Falholt K., 1987, Intracellular metabolic effects of fast‐acting monomeric insulins, Diabetologia, 30, 518A
  3. Falholt K., 1988, Glycogen metabolism in pigs treated with monomeric insulin analog, Diabetes Res Clin Prac, 5, S236
  4. Falholt K., 1989, Intermediary metabolism after treatment with very fast acting human MG‐insulin, Diabetologia, 32, 486A
  5. Sodoyez‐Goffaux F., 1991, Effect of affinity of insulin and ‘monomeric’ analogues upon interaction with insulin receptors. In vivo studies, Diabetologia, 34, A27
  6. Kruse V., 1989, Scintigraphic studies in rats of insulin analogues having from zero to five times the receptor affinity of insulin, Diabetologia, 32, 506A
  7. Wolpert H., 1990, Identification of an insulin analog with enhanced growth effect in aortic smooth muscle cells, Diabetes, 39, 140A

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Metadata

Authors
Gelding, S. V., Coldham, N., Anyaoku, V., Heslop, K., Halliday, D., & Johnston, D. G.
Affiliations
St Mary's Hospital (GB)
Corresponding author
Gelding, S. V.
Venue
Diabetic Medicine
Publisher
Wiley
Published
1993-06
Volume
10
Issue
5
Pages
470-476
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1111/j.1464-5491.1993.tb00101.x
OpenAlex
W1981639657
Cited by
4
References
37
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5903 d)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
insulin analogues, insulin receptor affinity, lipolysis, glycerol turnover, fatty acid levels, glucose turnover, leucine turnover, insulin clearance
MeSH terms
Adult, Blood Glucose, Carbon Isotopes, Deuterium, Fatty Acids, Nonesterified, Female, Glycerol, Humans, Insulin, Lipolysis, Male, Recombinant Proteins, Reference Values

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