The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
The molecular biology of chronic wounds and delayed healing in diabetes
Abstract
Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.
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In the citing paper
“Diabetics typically suffer from delayed and diminished wound healing.127”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [127]
In the citing paper
“During impaired healing associated with diabetes, wounds exhibit prolonged accumulation of Mp associated with elevated levels of proinflammatory cytokines and proteases and reduced levels of various growth factors (2,12,13).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [2]
Citations
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Cited by
Sorted by citations
Krzyszczyk, P., Schloss, R. S., Palmer, A. F., & Francois Berthiaume, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,606
Inflammation in Chronic Wounds
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Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights
Baltzis, D., Eleftheriadou, I., & Veves, A. (2014) · Advances in Therapy · doi:10.1007/s12325-014-0140-x · Cited by 755
Curcumin as a wound healing agent
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Metadata
- Authors
- Blakytny, R., & Jude, E.
- Affiliations
- Fachklinik Hornheide (DE)
- Tameside Hospital (GB)
- Corresponding author
- Jude, E.
- ORCID
- Jude, E.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 23
- Issue
- 6
- Pages
- 594-608
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1967162280
- Cited by
- 632
- References
- 224
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications
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