The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Short- and long-term effects of endurance training in patients with mitochondrial myopathy
Abstract
BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.
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Although oxidative capacity is improved by exercise, there are no changes in the mtDNA mutation load.
“However, others have reported that although oxidative capacity is improved, there are no changes in the mtDNA mutation load (Jeppesen et al., 2009; Taivassalo et al., 2006).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Jeppesen et al., 2009
Citations
Cites
Taivassalo, T., Gardner, J. L., Taylor, R. W., Schaefer, A. M., Newman, J., Barron, M. J., Haller, R. G., & Turnbull, D. M. (2006) · Brain · doi:10.1093/brain/awl282 · Cited by 220
Taivassalo, T., Shoubridge, E. A., Chen, J. M., Kennaway, N. G., DiMauro, S., Arnold, D. L., & Haller, R. G. (2001) · Annals of Neurology · doi:10.1002/ana.1050 · Cited by 213
Aerobic training is safe and improves exercise capacity in patients with mitochondrial myopathy
Jeppesen, T. D., Schwartz, M., Olsen, D. B., Wibrand, F., Krag, T., Duno, M., Hauerslev, S., & Vissing, J. (2006) · Brain · doi:10.1093/brain/awl149 · Cited by 211
Apoptosis in mitochondrial myopathies is linked to mitochondrial proliferation
Auré, K., Fayet, G., Leroy, J. P., Lacène, E., Romero, N. B., & Lombès, A. (2006) · Brain · doi:10.1093/brain/awl061 · Cited by 79
Adhihetty, P. J., Taivassalo, T., Haller, R. G., Walkinshaw, D. R., & Hood, D. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2007 · Cited by 75
Giovanni, S. D., Massimiliano Mirabella, A., Papacci, M., Odoardi, F., Silvestri, G., & Servidei, S. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.0970 · Cited by 56
Functional Diagnostics in Mitochondrial Diseases
Siciliano, G., Volpi, L., Piazza, S., Ricci, G., Mancuso, M., & Murri, L. (2007) · Bioscience Reports · doi:10.1007/s10540-007-9037-0 · Cited by 51
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Parikh, S., Goldstein, A., Koenig, M. K., Scaglia, F., Enns, G. M., Saneto, R., Anselm, I., Cohen, B. H., Falk, M. J., Greene, C., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2014.177 · Cited by 607
Mitochondria, Muscle Health, and Exercise with Advancing Age
Carter, H. N., Chen, C. C. W., & Hood, D. A. (2015) · Physiology · doi:10.1152/physiol.00039.2014 · Cited by 191
DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180
Metadata
- Authors
- Jeppesen, T. D., Dunø, M., Schwartz, M., Krag, T., Rafiq, J., Wibrand, F., & Vissing, J.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Jeppesen, T. D.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2009-11-17
- Volume
- 16
- Issue
- 12
- Pages
- 1336-1339
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W1978977765
- Cited by
- 46
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- mitochondrial myopathy, mitochondrial DNA mutations, endurance training, exercise intolerance, oxidative capacity, deconditioning, training safety, muscle morphology, exercise capacity
- MeSH terms
- Exercise Therapy, Humans, Time, Exercise Tolerance, Mitochondrial Myopathies, Muscle, Skeletal
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