Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: a community study.
Abstract
Background and purpose: Uncertain prognosis and modest treatment efficacy make multiple sclerosis (MS) a particularly difficult disease to adjust to for both patients and their significant others (SOs). Few studies have assessed health‐related quality of life (HRQOL) and depressive symptoms in SOs of people with MS in the community. We assessed, and identified predictors of, HRQOL and depression in SOs of adults with MS. Methods: POSMOS (postal survey of self‐assessed health in MS adults and SOs) is a longitudinal survey on a random sample of 251 people with MS in the Milan area. In 2010, SOs and contemporaneous controls completed the SF‐36 and Chicago Multiscale Depression Inventory (CMDI). Results: Overall, 142 SOs (mean age 53.1 years; 50% women, 65% partners) and 120 controls (similar to SOs for sex and education, but older) participated. By multivariable modeling of the SO plus control population, SF‐36 vitality was lower in SOs (proportional odds ratio 0.45; 95% confidence interval 0.28–0.70), women (0.41; 0.27–0.64), and older subjects (0.98; 0.97–0.99). SF‐36 mental health was also lower in SOs (0.62; 0.40–0.96) and women (0.43; 0.28–0.67). Regarding MS characteristics associated with HRQOL and depression in SOs, severe disability [Expanded Disability Status Scale (EDSS > 6.5)] had no effect, whilst depressive symptoms (pathologic CMDI) negatively influenced most SF‐36 and all CMDI scores in SOs. Conclusions: SOs had significantly lower vitality and psychological well‐being than controls, identifying a burden in being the companion of a person with MS. This burden was unrelated to physical compromise but associated with depressive symptoms in MS.
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Patients' depressive state influences the deterioration of QoL and the depression of caregivers.
“In fact, a recent study has shown that patients’ depressive state influences the deterioration of QoL and the depression of caregivers [49].”
Caregivers of patients with MS experience stress and difficulties related to managing a relative with a chronic disabling disease, and patients' depression has a negative impact on the quality of life and mood of their caregivers.
“Caregivers of patients with MS experience the stress and difficulties related to the management of a relative with a chronic disabling disease. Furthermore, patients’ depression has a negative impact on the quality of life and mood of their caregivers (Giordano et al., 2012).”
From The effectiveness of a body-affective mindfulness intervention for multiple sclerosis patients with depressive symptoms: A randomized controlled clinical trial (2017) · cites this paper as Giordano et al., 2012
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- Authors
- Giordano, A., Ferrari, G., Radice, D., Randi, G., Bisanti, L., Solari, A., & study, O. B. O. T. P.
- Affiliations
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- European Institute of Oncology (IT)
- Corresponding author
- Solari, A.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2012-01-10
- Volume
- 19
- Issue
- 6
- Pages
- 847-854
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2123304507
- Cited by
- 35
- References
- 28
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
- Keywords
- multiple sclerosis, significant others, health-related quality of life, depressive symptoms, caregiver burden, vitality, mental health, disability severity, Expanded Disability Status Scale, family caregivers, sex differences
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Depression, Disability Evaluation, Female, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Quality of Life, Regression Analysis, Residence Characteristics, Retrospective Studies, Young Adult
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