Fisher's 'Fundamental Theorem' Made Clear
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If the mutational spectrum is such that mutations are neutral on average, then Fisher's Fundamental Theorem of Natural Selection predicts that biological fitness increases over time, corresponding to a large prevalence P(A).
“If the mutational spectrum is such that mutations are neutral on average, then Fisher's Fundamental Theorem of Natural Selection (Fisher, 1930, Price, 1972) predicts that biological fitness increases over time, corresponding to a large prevalence P A ð Þ.”
From Using statistical methods to model the fine-tuning of molecular machines and systems (2020) · cites this paper as Price, 1972
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The evolutionary genetics of personality
Penke, L., Denissen, J. J. A., & Miller, G. F. (2007) · European Journal of Personality · doi:10.1002/per.629 · Cited by 610 · see citing works
The fundamental theorem of natural selection with mutations
Basener, W. F., & Sanford, J. C. (2018) · Journal of Mathematical Biology · doi:10.1007/s00285-017-1190-x · Cited by 46 · see citing works
Using statistical methods to model the fine-tuning of molecular machines and systems
Thorvaldsen, S., & Hössjer, O. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110352 · Cited by 15 · see citing works
“If the mutational spectrum is such that mutations are neutral on average, then Fisher’s Fundamental Theorem of Natural Selection (Fisher, 1930, Price, 1972) predicts that biological fitness increases over time, corresponding to a large prevalence P Að Þ.”
Background
- Authors
- PRICE, G. R.
- Affiliations
- University College London (GB)
- Corresponding author
- PRICE, GEORGE R.
- Venue
- Annals of Human Genetics
- Publisher
- Wiley
- Published
- 1972-11
- Volume
- 36
- Issue
- 2
- Pages
- 129-140
- ISSN
- 0003-4800 (ISSN-L)
- 1469-1809
- OpenAlex
- W2035290744
- Cited by
- 410
- References
- 0
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 15 · 2023: 22 · 2022: 15 · 2021: 16 · 2020: 21 · 2019: 35 · 2018: 17 · 2017: 22 · 2016: 16 · 2015: 15 · 2014: 22 · 2013: 15 · 2012: 14
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- Fisher's fundamental theorem, natural selection, genetic variance, heritability
- MeSH terms
- Biological Evolution, Genetics, Population, Humans, Mathematics, Models, Biological, Physical Fitness, Time Factors, Genetic Variation
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