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Cited by 83Craniofacial Disorders and TreatmentsMorphological variations and asymmetryPectus Deformity Diagnosis and Treatment

Relationship of brain and skull in pre- and postoperative sagittal synostosis

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Aldridge, Kristina, Kane, Alex A., Marsh, Jeffrey L., Yan, Peng, Govier, Daniel, Richtsmeier, Joan T.·2005·Journal of Anatomy
DOI 10.1111/j.1469-7580.2005.00397.xPMC PMC1571486
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Abstract

Models of vertebrate skull evolution stress the coordinated developmental relationship between the skull and the brain that it houses. This study investigates the relationship between altered skull morphology and brain morphology in premature fusion of the cranial sagittal suture (isolated sagittal synostosis; ISS), a condition associated with dysmorphology of both neurocranium and brain. Although the skull displays a more normal shape following reconstructive cranial vault surgery, effects of this surgery on the brain have not been investigated. Landmark coordinate data were collected from three-dimensional magnetic resonance imaging reconstructions of the brain in a sample of ISS patients and an age-matched unaffected cohort. These data were analysed using Euclidean distance matrix analysis (EDMA). Results show that the brain in ISS is dysmorphic preoperatively, displaying a posteriorly directed neural expansion that does not 'worsen' with growth. Postoperatively, the brain in ISS displays a more globular shape overall as compared with the preoperative morphology, but differs from normal in its subcortical morphology. These results show that the ISS brain is altered following neurocranial surgery, but does not more closely approximate that of unaffected individuals. This suggests that although the brain is affected by manipulation of the skull, it retains a growth pattern that is, at least in part, independent of the skull.

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Crossref · 10.1111/j.1469-7580.2005.00397.x

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  • In ISS, the brain becomes longer than in normocephalic children, with narrowing of the occipital lobes, lengthening of the lateral ventricles, lateral widening of the frontal lobes, slight backward displacement of the thalamus and deep nuclei, and altered distribution of subarachnoid spaces.

    “It is clear that changes in the shape of the cranial sulcus can also affect the deformation and shape of the brain itself [13], which becomes longer in ISS compared to normocephalic children. In addition, other deformities are characteristic of the ISS brain, in particular the narrowing of the occipital lobes, the lengthening of the lateral ventricles, and the lateral widening of the frontal lobes”

    From Isolated Sagittal Craniosynostosis: A Comprehensive Review (2024) · cites this paper as [13]

    The Results report that preoperative ISS brains are longer anteroposteriorly than unaffected brains and show localized frontal widening. They do not establish narrowing of the occipital lobes, lengthening of the lateral ventricles, backward displacement of the thalamus or deep nuclei, or altered subarachnoid-space distribution. Page numbers were not supplied for the indexed passages. (LLM, conf=0.86)

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Cites

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3 of the 66 references couldn’t be matched to a known paper.

Research works printed but not linked: 13

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Authors
Aldridge, K., Kane, A. A., Marsh, J. L., Yan, P., Govier, D., & Richtsmeier, J. T.
Affiliations
  • Pennsylvania State University (US)
  • St. Louis Children's Hospital (US)
  • Sisters of Mercy Health System (US)
Corresponding author
Aldridge, Kristina
ORCID
Venue
Journal of Anatomy
Publisher
Wiley
Published
2005-03-30
Volume
206
Issue
4
Pages
373-385
ISSN
  • 0021-8782 (ISSN-L)
  • 1469-7580
DOI
10.1111/j.1469-7580.2005.00397.x
PMC
PMC1571486
OpenAlex
W2107303439
Cited by
83
References
66
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 6
FWCI
1.26
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Anatomy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Dental and Craniofacial Research (1 P60 DE13078, P60DE013078)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
  • Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
  • Health Sciences › Medicine › Surgery › Pectus Deformity Diagnosis and Treatment
Keywords
craniosynostosis, cranial vault reconstruction, brain structure, neurocranium, skull evolution
MeSH terms
Brain, Child, Preschool, Craniosynostoses, Humans, Infant, Magnetic Resonance Imaging, Postoperative Period, Skull, Tomography, X-Ray Computed, Case-Control Studies, Imaging, Three-Dimensional

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