The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Mitochondrial intermembrane junctional complexes and their role in cell death
Open accessAbstract
A mitochondrial complex comprising the voltage‐dependent anion channel (outer membrane), the adenine nucleotide translocase (inner membrane) and cyclophilin‐D (matrix) assembles at contact sites between the inner and outer membranes. Under pathological conditions associated with ischaemia and reperfusion the junctional complex ‘deforms’ into the permeability transition (PT) pore, which can open transiently, allowing free permeation of low Mr solutes across the inner membrane. This may be a critical step in the pathogenesis of lethal cell injury in ischaemia and reperfusion. Moreover, it is argued, the degree of pore opening may be an important determinant of the relative extent of apoptosis and necrosis under these conditions. In addition, mitochondria are the major sites of action of Bax and other apoptotic regulatory proteins of the Bcl‐2 family. These proteins control a mitochondrial amplificatory loop in the apoptotic signalling pathway in which cytochrome c and other apoptogenic proteins of the mitochondrial intermembrane space are released into the cytosol. There are indications that the junctional complex, or components of it, may also mediate the action of Bax, but in a way that does not involve PT pore formation.
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Cites
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The role of apoptosis in response to photodynamic therapy: what, where, why, and how
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What is the mitochondrial permeability transition pore?
Halestrap, A. P. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.02.021 · Cited by 933
Mitochondria in health and disease: perspectives on a new mitochondrial biology
Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 721
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 709
MuSiC: Identifying mutational significance in cancer genomes
Dees, N. D., Zhang, Q., Kandoth, C., Wendl, M. C., Schierding, W., Koboldt, D. C., Mooney, T. B., Callaway, M. B., Dooling, D., Mardis, E. R., et al. (2012) · Genome Research · doi:10.1101/gr.134635.111 · Cited by 677
Metadata
- Authors
- Crompton, M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2000-11
- Volume
- 529
- Issue
- 1
- Pages
- 11-21
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2160002590
- Cited by
- 317
- References
- 90
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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