CoChat
Sign Up
Cited by 47Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

Serotonin suppresses subthreshold and suprathreshold oscillatory activity of rat inferior olivary neurones in vitro

Open access
Placantonakis, Dimitris G., Schwarz, Cornelius, Welsh, John P.·2000·The Journal of Physiology
DOI 10.1111/j.1469-7793.2000.00833.xPMC PMC2269901
Open this paper in CoChat — free account

Abstract

The effect of serotonin on membrane potential oscillations of inferior olivary neurones was studied in brainstem slices from 10- to 19-day-old rats. Serotonin at 50 and 5 microM induced a mean depolarization of 9.4 and 7.7 mV, respectively, that was preceded by a reversible suppression of subthreshold membrane potential oscillations. These effects were not changed by 1 microM tetrodotoxin and the suppression of subthreshold oscillations persisted after current-mediated restoration of resting potential. In spontaneously active neurones, serotonin abolished the rhythmicity of action potential firing without affecting spike frequency. Serotonin reduced the slope of the calcium-mediated rebound spike and both the duration and amplitude of the subsequent afterhyperpolarization. Serotonin also shifted the voltage dependence of the rebound spike to more negative values. Hyperpolarizing current pulses (200 ms) revealed that serotonin increased the pre-rectification and steady-state components of membrane resistance by 37 and 38 %, respectively, in 66 % of neurones, but decreased these parameters by 14 and 20% in the remaining cells. The serotonin effects were antagonized by 5 microM methysergide or 1-5 microM ketanserin and were mimicked by 10-20 microM dimethoxy-4-iodoamphetamine but not 10 microM 8-hydroxy-2-(di-N-propylamino)-tetralin. The data indicate that serotonin suppresses the rhythmic activity of olivary neurones via 5-HT2 receptors by inhibition of the T-type calcium current in combination with membrane depolarization due to activation of a cation current (Ih) and block of a resting K+ current (fast IK(ir)). This modulatory action of serotonin may account for the differential propensity of olivary neurones to fire rhythmically during different behavioural states in vivo.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1469-7793.2000.00833.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Serotonin and NMDA receptors within the IO can potently modulate cerebellar output, either by changing HCN and Cav3.1 channel activity after 5-HT2A receptor activation to modulate pacemaking, or by changing spatial patterns of electrotonic coupling after NMDA receptor activation to regulate synchronous spiking in the cerebellum.

    “Serotonin and NMDA receptors within the IO can potently modulate cerebellar output, either by changing HCN and Cav3.1 channel activity after 5-HT2A receptor activation to modulate pacemaking [266, 267], or by changing spatial patterns of electrotonic coupling after NMDA receptor activation to regulate synchronous spiking in the cerebellum [268].”

    From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [266]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. DeZeeuw CI. Ultrastructure of the Cat Inferior Olive. Rotterdam, The Netherlands: Universiteits Erasmus Drukkerij; 1990. [Google Scholar]
  2. Fahn S, Marsden CD, Van Woert MH. Advances in Neurology. vol. 43. New York: Raven Press; 1986. Myoclonus. [PubMed] [Google Scholar]
  3. Fuxe K, Agnati LF. Two principal modes of electrochemical communication in the brain: Volume versus wiring transmission. In: Fuxe K, Agnati LF, editors. Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission. New York: Raven Press; 1991. pp. 1–9. [Google Scholar]
  4. Placantonakis DG, Schwarz C, Welsh JP. Serotonin suppresses subthreshold oscillations in the inferior olive. Society for Neuroscience Abstracts. 1998;24:665. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Placantonakis, D. G., Schwarz, C., & Welsh, J. P.
Affiliations
New York University (US)
Corresponding author
Welsh, John P.
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2000-05
Volume
524
Issue
3
Pages
833-851
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.2000.00833.x
PMC
PMC2269901
OpenAlex
W2069598304
Cited by
47
References
47
Citations by year
2023: 1 · 2021: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 7
FWCI
0.90
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS31224, R56NS031224, R01NS031224)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
serotonin, inferior olive, membrane potential oscillations, 5-HT2 receptor, T-type calcium current, Ih current, afterhyperpolarization, methysergide, ketanserin, rhythmic neuronal activity, brainstem slices
MeSH terms
Action Potentials, Amphetamines, Animals, Cardiovascular Agents, Electrophysiology, Ketanserin, Methysergide, Neurons, Olivary Nucleus, Periodicity, Pyrimidines, Serotonin, Serotonin Antagonists, Potassium Channels, Electric Impedance, Rats, Sprague-Dawley, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Potassium Channels, Inwardly Rectifying, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review