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Cited by 54Neuroscience of respiration and sleepRespiratory and Cough-Related ResearchTransplantation: Methods and Outcomes

Changes in respiratory sensations induced by lobeline after human bilateral lung transplantation.

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Butler, J. E., Anand, A., Crawford, M. R., Glanville, A. R., McKenzie, D. K., Paintal, A. S., Taylor, J. L., Gandevia, S. C.·2001·The Journal of Physiology
DOI 10.1111/j.1469-7793.2001.00583.xPMC PMC2278721
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Abstract

1. The sensations evoked by the injection of lobeline into the right antecubital vein were studied in 8 subjects after bilateral lung transplantation and 10 control subjects. In control subjects, two distinct sensations were experienced. There was an early noxious sensation (onset approximately 10 s) followed by a late sensation of breathlessness (onset approximately 26 s) associated with involuntary hyperventilation. The early sensation was accompanied by respiratory and cardiovascular changes. 2. In contrast to control subjects, the early respiratory events and the noxious sensations evoked by injections of lobeline (18-60 microg kg(-1)) did not occur in subjects with recent bilateral lung transplantation. This suggests that the early respiratory sensations are mediated by the discharge of receptors in the lungs. 3. The late hyperventilation and the accompanying sensation of breathlessness occurred in both transplant and control subjects and are therefore likely to be mediated by receptors elsewhere in the body, presumably systemic arterial chemoreceptors stimulated by lobeline. 4. In control subjects, but not transplant subjects, there was a consistent decrease in mean arterial pressure associated with the lobeline injection. This suggests that pulmonary afferents mediate the hypotension. 5. For transplant subjects studied more than a year after transplantation, there was some evidence that the noxious respiratory sensations evoked by lobeline had returned. This suggests that some functional reinnervation of pulmonary afferents may occur.

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Research works printed but not linked: 3

  1. Gandevia SC, Butler JE, Anand A, Crawford MR, Glanville AR, Paintal AS, Taylor JL, McKenzie DK. Sensations attributable to intrapulmonary afferents: Responses to lobeline in control subjects and patients with lung transplants. Proceedings of the Australian Neuroscience Society. 1998a;9:74P. [Google Scholar]
  2. Ginzel KH, Eldred E. A possible physiological role for the depression of somatic motor function by reflexes from the cardiopulmonary region. Proceedings of the Western Pharmacological Society. 1970;13:188–191. [Google Scholar]
  3. Kalia M, Koepchen HP, Paintal AS. Somatomotor and autonomous effects of type-J receptor stimulation in awake freely-moving and restrained cats. Pflügers Archiv. 1973;339:R80. [Google Scholar]

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Authors
Butler, J. E., Anand, A., Crawford, M. R., Glanville, A. R., McKenzie, D. K., Paintal, A. S., Taylor, J. L., & Gandevia, S. C.
Affiliations
  • UNSW Sydney (AU)
  • University of Delhi (IN)
  • Prince of Wales Hospital (AU)
  • St Vincent's Hospital Sydney (AU)
Corresponding author
Gandevia, S. C.
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2001-07
Volume
534
Issue
2
Pages
583-593
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.2001.00583.x
PMC
PMC2278721
OpenAlex
W2058481247
Cited by
54
References
36
Citations by year
2023: 3 · 2022: 1 · 2021: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1131 d)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
lobeline, bilateral lung transplantation, respiratory sensation, hyperventilation, dyspnea, arterial chemoreceptors, mean arterial pressure, respiratory reflexes
MeSH terms
Adult, Aged, Blood Pressure, Dyspnea, Female, Heart Rate, Humans, Injections, Intravenous, Lobeline, Lung, Male, Middle Aged, Neurons, Afferent, Nociceptors, Sensation, Lung Transplantation, Respiratory System Agents

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