The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review*
Open accessAbstract
Aim To review systematically the neurodevelopmental characteristics of individuals with sex chromosome trisomies (SCTs). Method A bibliographic search identified English‐language articles on SCTs. The focus was on studies unbiased by clinical referral, with power of at least 0.69 to detect an effect size of 1.0. Results We identified 35 articles on five neonatally identified samples that had adequate power for our review. An additional 11 studies were included where cases had been identified for reasons other than neurodevelopmental concerns. Individuals with an additional X chromosome had mean IQs that were within broadly normal limits but lower than the respective comparison groups, with verbal IQ most affected. Cognitive outcomes were poorest for females with XXX. Males with XYY had normal‐range IQs, but all three SCT groups (XXX, XXY, and XYY) had marked difficulties in speech and language, motor skills, and educational achievement. Nevertheless, most adults with SCTs lived independently. Less evidence was available for brain structure and for attention, social, and psychiatric outcomes. Within each group there was much variation. Interpretation Individuals with SCTs are at risk of cognitive and behavioural difficulties. However, the evidence base is slender, and further research is needed to ascertain the nature, severity, and causes of these difficulties in unselected samples.
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An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
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Behavioral and Social Phenotypes in Boys With 47,XYY Syndrome or 47,XXY Klinefelter Syndrome
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Patterns of psychopathology and cognition in sex chromosome aneuploidy
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Metadata
- Authors
- LEGGETT, V., JACOBS, P., NATION, K., SCERIF, G., & BISHOP, D. V. M.
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2010-01-15
- Volume
- 52
- Issue
- 2
- Pages
- 119-129
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W1861196653
- Cited by
- 291
- References
- 42
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- LEGGETT, V., JACOBS, P., NATION, K., SCERIF, G., & BISHOP, D. V. M. (2010). Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review*. Developmental Medicine & Child Neurology. https://doi.org/10.1111/j.1469-8749.2009.03545.x
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