METABOLIC EFFECTS OF BETA‐SYMPATHOMIMETIC DRUGS AND DEXAMETHASONE IN NORMAL AND DIABETIC PREGNANCY
Abstract
Summary: Marked hyperglycaemia and hyperinsulinaemia were observed in two normal women in premature labour treated with an intravenous infusion of a β‐sympathomimetic drug and intramuscular dexamethasone injections. Similar therapy in a chemical diabetic patient caused diabetic ketoacidosis, while treatment of an insulin dependent diabetic with dexamethasone alone resulted in a major increase in her insulin requirements. It is suggested that the diabetogenic effects of β‐sympathomimetic drugs and dexamethasone may be additive and that regular plasma glucose estimations should be made when they are used, especially in patients with impaired glucose tolerance.
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In pregnancy, the baseline insulin-resistant state amplifies glucocorticoid effects, explaining the dramatic increases in insulin requirements and heightened risk of severe decompensation.
“In pregnancy, the baseline insulin‐resistant state amplifies GC effects, explaining the dramatic increases in insulin requirements and heightened risk of severe decompensation.”
From A systematic review of glucocorticoid use in type 1 diabetes: Glycaemic effects and clinical management strategies (2026) · cites this paper as [44]
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Katz, A., Shulkin, A., Housni, A., Roy‐Fleming, A., Rabasa‐Lhoret, R., Yale, J., Tsoukas, M. A., Peters, T. M., & Brazeau, A. (2026) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.70465 · Cited by 3 · see citing works
- Authors
- Borberg, C., Gillmer, M. D. G., Beard, R. W., & Oakley, N. W.
- Affiliations
- St Mary's Hospital (GB)
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1978-03
- Volume
- 85
- Issue
- 3
- Pages
- 184-189
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2018976918
- Cited by
- 24
- References
- 19
- Citations by year
- 2026: 1 · 2017: 1
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- dexamethasone, pregnancy, diabetes mellitus, hyperglycemia, hyperinsulinemia, diabetic ketoacidosis, insulin requirement, impaired glucose tolerance, premature labour, diabetogenic effect
- MeSH terms
- Adolescent, Adrenergic beta-Agonists, Adult, Blood Glucose, Dexamethasone, Drug Synergism, Female, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Obstetric Labor, Premature, Pregnancy, Pregnancy in Diabetics
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