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The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome
Abstract
Summary. The influence of norethisterone on mood and behaviour was investigated in prospective placebo‐controlled study in 58 postmenopausal hysterectomized women who were being treated with subcutaneous oestradiol and testosterone implants. Norethisterone, 2·5 or 5 mg daily, was given for 7 days and a placebo for two periods of 7 days. Psychological, behavioural and physical variables were assessed using the Menstrual Distress Questionnaire. There were widespread adverse effects which were dose‐related. Significant changes in five of the eight symptom complexes studied (pain, concentration, behavioural change, water retention and negative affect) were found with 5 mg/day of the progestogen. The symptoms were similar to the typical complaints of the premenstrual syndrome, such that a combination of oestradiol and testosterone implants with cyclical oral norethisterone appears to be a model for this condition. The dose of this progestogen should therefore be the minimum to achieve the desired therapeutic effect.
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Citations
Cited by
Effects of gonadal steroids in women with a history of postpartum depression
Bloch, M., Schmidt, P. J., Danaceau, M., Murphy, J., Nieman, L., & Rubinow, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.924 · Cited by 950
Estrogen replacement in perimenopause-related depression: A preliminary report
Schmidt, P. J., Nieman, L., Danaceau, M. A., Tobin, M. B., Roca, C. A., Murphy, J. H., & Rubinow, D. R. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106004 · Cited by 578
Estrogen and cognitive functioning in women
Sherwin, B. B. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0016 · Cited by 560
A meta-analysis of the effect of hormone replacement therapy upon depressed mood
Zweifel, J. E., & O'Brien, W. H. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(96)00034-0 · Cited by 330
Greendale, G. (1998) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(98)00305-6 · Cited by 317
Metadata
- Authors
- MAGOS, A. L., BREWSTER, E., SINGH, R., O'DOWD, T., BRINCAT, M., & STUDD, J. W. W.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1986-12
- Volume
- 93
- Issue
- 12
- Pages
- 1290-1296
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2014035121
- Cited by
- 210
- References
- 0
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome. https://app.cochat.ai/papers/10.1111/j.1471-0528.1986.tb07868.x
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- MAGOS, A. L., BREWSTER, E., SINGH, R., O'DOWD, T., BRINCAT, M., & STUDD, J. W. W. (1986). The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome. BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/j.1471-0528.1986.tb07868.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
