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Genetics of hypertension in pregnancy: possible single gene control of pre‐eclampsia and eclampsia in the descendants of eclamptic women
Abstract
Summary. Our report concerns the incidences of pre‐eclampsia and eclampsia in 147 sisters, 248 daughters, 74 granddaughters, and 131 daughters‐in‐law of women who have had eclampsia. The disorder is highly heritable. We have analysed the data in two ways, firstly, as a single gene condition and, secondly, as a multifactorial condition. The observed incidences fit closely with the single gene model with frequency of the putative gene being 0.25. When Falconer's method of estimating heritabilities of discrete characters is used, estimates of 120% (sisters), 88% (daughters), and 105% (granddaughters)—none significantly different from 100%—are obtained. Insofar as possible, our definition of pre‐eclampsia corresponds with EPH in the descriptive classification of the Organisation Gestosis and to ‘severe pre‐eclampsia’ in Nelson's classification. The women were delivered in many different hospitals, however, and many records fail to provide all of the essential information
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Citations
Cited by
Gestational Hypertension and Preeclampsia
(2020) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000003891 · Cited by 2,949
Practice Bulletin No. 183: postpartum hemorrhage
(2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002351 · Cited by 1,406
Dimitriadis, E., Rolnik, D. L., Zhou, W., Estrada-Gutierrez, G., Koga, K., Francisco, R. P. V., Whitehead, C., Hyett, J., da Silva Costa, F., Nicolaides, K., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00417-6 · Cited by 866
Fetal and maternal contributions to risk of pre-eclampsia: population based study
Lie, R. T., Rasmussen, S., Brunborg, H., Gjessing, H. K., Lie-Nielsen, E., & Irgens, L. M. (1998) · BMJ · doi:10.1136/bmj.316.7141.1343 · Cited by 461
(1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90653-o · Cited by 438
Metadata
- Authors
- CHESLEY, L. C., & COOPER, D. W.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1986-09
- Volume
- 93
- Issue
- 9
- Pages
- 898-908
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2047053047
- Cited by
- 264
- References
- 0
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetics of hypertension in pregnancy: possible single gene control of pre‐eclampsia and eclampsia in the descendants of eclamptic women. https://app.cochat.ai/papers/10.1111/j.1471-0528.1986.tb08006.x
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- CHESLEY, L. C., & COOPER, D. W. (1986). Genetics of hypertension in pregnancy: possible single gene control of pre‐eclampsia and eclampsia in the descendants of eclamptic women. BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/j.1471-0528.1986.tb08006.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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