The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre‐operative diagnosis of pelvic masses
Abstract
Objective To evaluate the ability of a risk of malignancy index (RMI), based on a serum CA125 level, ultrasound findings and menopausal status, to discriminate a benign from a malignant pelvic mass and to discriminate early stage (Figo Stage I) from Stages II, III and IV of ovarian cancer. Design A prospective study. Setting Department of Gynaecology, Trondheim University Hospital, Trondheim, Norway. Participants One hundred and seventy‐three women, 30 years or older, consecutively admitted between February 1992 and February 1994 for primary laparotomy of a pelvic mass. Main outcome measures The sensitivity, specificity and positive predictive value of serum CA125 level, ultrasound findings and menopausal status, separately and combined into the RMI, to diagnose ovarian cancer. Results The RMI was more accurate than any individual criterion in diagnosing cancer. Using a RMI cut‐off level of 200 to indicate malignancy, the RMI derived from this dataset gave a sensitivity of 80%, specificity of 92% and positive predictive value of 83%. Applying RMI criteria developed by others, the following test performance was found: sensitivity 71%, specificity 96% and positive predictive value 89%. For the Stages II, III and IV of ovarian cancer the sensitivity increased to approximately 90% without any substantial loss in specificity. Conclusions The risk of malignancy index is able to correctly discriminate between malignant and benign pelvic masses. It is a scoring system which can be introduced easily into clinical practice to facilitate the selection of patients for primary surgery at an oncological unit.
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Granberg, S., Wikland, M., & Jansson, I. (1989) · Gynecologic Oncology · doi:10.1016/0090-8258(89)90031-0 · Cited by 301
Transvaginal colour flow imaging: a possible new screening technique for ovarian cancer.
Bourne, T., Campbell, S., Steer, C., Whitehead, M. I., & Collins, W. P. (1989) · BMJ · doi:10.1136/bmj.299.6712.1367 · Cited by 301
Malkasian, G. D., Knapp, R. C., Lavin, P. T., Zurawski, V. R., Podratz, K. C., Stanhope, C. R., Mortel, R., Berek, J. S., Bast, R. C., & Ritts, R. E. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(88)80081-4 · Cited by 227
Evaluation of adnexal masses with transvaginal color ultrasound.
Kurjak, A., Žalud, I., & Alfirević, Ž. (1991) · Journal of Ultrasound in Medicine · doi:10.7863/jum.1991.10.6.295 · Cited by 218
The influence of the operating surgeon's specialisation on patient survival in ovarian carcinoma
Kehoe, S., Powell, J., Wilson, S., & Woodman, C. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.440 · Cited by 163
The adnexal mass: benign or malignant? Evaluation of a risk of malignancy index
Davies, A. P., Jacobs, I. J., Woolas, R. P., et al. (1993) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1993.tb15109.x · Cited by 147
Serum CA 125 levels in preoperative evaluation of pelvic masses.
Vasilev, S. A., Schlaerth, J. B., Campeau, J., & Morrow, C. P. (1988) · PubMed · Cited by 134
Levin, L., Lund, B., & Heintz, A. P. M. (1993) · Annals of Oncology · doi:10.1093/annonc/4.suppl_4.s23 · Cited by 29
Debulking and intervention surgery
Hacker, N. F., & van der Burg, M. E. L. (1993) · Annals of Oncology · doi:10.1093/annonc/4.suppl_4.s17 · Cited by 28
Cited by
Complex Adnexal Masses: Detection and Characterization with MR Imaging—Multivariate Analysis
Hricak, H., Chen, M., Coakley, F. V., Kinkel, K., Yu, K. K., Sica, G., Bacchetti, P., & Powell, C. B. (2000) · Radiology · doi:10.1148/radiology.214.1.r00ja3939 · Cited by 294
Molecular Biomarkers for the Early Detection of Ovarian Cancer
Zhang, R., Siu, M. K. Y., Ngan, H. Y. S., & Chan, K. K. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912041 · Cited by 283
Kinkel, K., Lu, Y., Mehdizade, A., Pelte, M.-F., & Hricak, H. (2005) · Radiology · doi:10.1148/radiol.2361041618 · Cited by 280
Timmerman, D., Verrelst, H., Bourne, T. H., De Moor, B., Collins, W. P., Vergote, I., & Vandewalle, J. (1999) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.1999.13010017.x · Cited by 134
External Validation of Diagnostic Models to Estimate the Risk of Malignancy in Adnexal Masses
Van Holsbeke, C., Van Calster, B., Bourne, T., Ajossa, S., Testa, A. C., Guerriero, S., Fruscio, R., Lissoni, A. A., Czekierdowski, A., Savelli, L., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0879 · Cited by 87
Metadata
- Authors
- Tingulstad, S., Hagen, B., Skjeldestad, F. E., Onsrud, M., Kiserud, T., Halvorsen, T., & Nustad, K.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1996-08
- Volume
- 103
- Issue
- 8
- Pages
- 826-831
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2037421127
- Cited by
- 349
- References
- 10
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tingulstad, S., Hagen, B., Skjeldestad, F. E., Onsrud, M., Kiserud, T., Halvorsen, T., & Nustad, K. (1996). Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre‐operative diagnosis of pelvic masses. BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/j.1471-0528.1996.tb09882.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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