THE EFFECTS OF 2‐DEOXY‐d‐GLUCOSE ON METABOLISM OF SLICES OF CEREBRAL CORTEX INCUBATED IN VITRO
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2-deoxyglucose (2-DG) is a glucose analog that can be used to mimic glucose restriction.
“2-deoxyglucose (2-DG), a glucose analog, can be used to mimic glucose restriction.”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [20]
2-DG has been shown to inhibit glucose uptake and glycolytic metabolism via non-competitive and competitive inhibition of hexokinase and phosphoglucose isomerase, respectively.
“2-DG has been shown to inhibit glucose uptake and glycolytic metabolism via non-competitive and competitive inhibition of hexokinase and phosphoglucose isomerase, respectively,20”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [20]
Cites
Localization of the primary metabolic block produced by 2-deoxyglucose
Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64988-9 · Cited by 780 · see citing works
Activity of Acetylcholine System in Cerebral Cortex of Various Unanesthetized Mammals
Tower, D. B., & Elliott, K. A. C. (1952) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1952.168.3.747 · Cited by 100 · see citing works
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Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000 · see citing works
Tower, D. B., & Young, O. M. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb12126.x · Cited by 189 · see citing works
Self-citationKumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.013 · Cited by 64 · see citing works
- Authors
- Tower, D. B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Tower, Donald B.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1958-12
- Volume
- 3
- Issue
- 2
- Pages
- 185-205
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2077370148
- Cited by
- 162
- References
- 2
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- 2-deoxyglucose, cerebral cortex slices, glucose metabolism, brain energy metabolism, glucose deprivation, in vitro incubation
- MeSH terms
- Cerebral Cortex, Deoxyglucose, Glucose, Humans, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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