SPECIFICITY AND KINETIC PROPERTIES OF MONOSACCHARIDE UPTAKE INTO GUINEA PIG CEREBRAL CORTEX IN VITRO
Abstract
Abstract— The uptake into the non‐raffinose space of cerebral cortex slices of a number of 14 C‐labelled glucose analogues has been studied. Evidence on competition with glucose for the transport process has been used to derive information on the substrate specificity of sugar uptake to the brain. The kinetic properties of the uptake of 2‐deoxygIucose indicate that the transport is a facilitated process rather than diffusion. Classical competition between glucose and 2‐deoxyglucose for transport is shown and arguments are advanced for regarding glucose as a competitive inhibitor of 2‐deoxyglucose transport. The apparent K m for deoxyglucose is 10 mM and for glucose is suggested to be of the order of 5 m m, The value of such a kinetic approach to sugar transport in various conditions is discussed.
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2-deoxyglucose (2-DG) is a glucose analog that can be used to mimic glucose restriction.
“2-deoxyglucose (2-DG), a glucose analog, can be used to mimic glucose restriction.”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [21]
2-DG has been shown to inhibit glucose uptake and glycolytic metabolism via non-competitive and competitive inhibition of hexokinase and phosphoglucose isomerase, respectively.
“2-DG has been shown to inhibit glucose uptake and glycolytic metabolism via non-competitive and competitive inhibition of hexokinase and phosphoglucose isomerase, respectively,20”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [21]
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Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000 · see citing works
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb03919.x · Cited by 807 · see citing works
Kumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.013 · Cited by 64 · see citing works
- Authors
- Bachelard, H. S.
- Corresponding author
- Bachelard, H. S
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1971-02
- Volume
- 18
- Issue
- 2
- Pages
- 213-222
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2108943156
- Cited by
- 154
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 2 · 2017: 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cerebral cortex, glucose transport, 2-deoxyglucose, substrate specificity, transport kinetics, competitive inhibition, carrier-mediated transport, glucose analogs, guinea pig brain
- MeSH terms
- Animals, Arabinose, Biological Transport, Carbon Isotopes, Cerebral Cortex, Diffusion, Galactose, Glucose, Guinea Pigs, Hexoses, Kinetics, Monosaccharides, Xylose, In Vitro Techniques
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