RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
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Journal of NeurochemistryVolume 29, Issue 1 p. 13-26 Free Access RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM Louis Sokoloff, Louis Sokoloff Laboratory of Cerebral Metabolism, U.S. Department of Health, Education, and Welfare, Public Health Service, Bethesda, MD 20014, U.S.A.Search for more papers by this author Louis Sokoloff, Louis Sokoloff Laboratory of Cerebral Metabolism, U.S. Department of Health, Education, and Welfare, Public Health Service, Bethesda, MD 20014, U.S.A.Search for more papers by this author First published: July 1977 https://doi.org/10.1111/j.1471-4159.1977.tb03919.xCitations: 629AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abbreviations used: DG 2-deoxy-d-glucose DG-6-P 2-deoxy-d-glucose-6-phosphate REFERENCES Bachelard H. S. (1971) J. Neurochem. 18: 213– 222. Bidder T. G. (1968) J. Neurochem. 15: 867– 874. Caveness W. F. (1969) in Basic Mechanisms of the Epilepsies ( H. H. Jasper, A. A. Ward & A. Pope, eds.) pp. 517– 534. Little, Brown, Boston . Collins R. C., Kennedy C., Sokoloff L. & Plum F. (1976) Arch Neurol. 33: 536– 542. Des Rosiers M. H., Kennedy C., Shinohara M. & Sokoloff L. (1976) Neurology 26, 346. Giarman N. J. & Roth R. H. (1964) Science 145: 583– 584. Hers H. G. (1957) Le Métabolisme du Fructose, p. 102. Editions Arscia, Bruxelles . Hubel D. H. & Wiesel T. N. (1968) J. Physiol. 195: 215– 243. Hubel D. H. & Wiesel T. N. (1972) J. comp. Neurol. 146: 421– 450. Kennedy C., Des Rosiers M. H., Reivich M., Sharp F., Jehle J. W. & Sokoloff L. (1975) Science 187: 850– 853. Kennedy C., Des Rosiers M. H., Sakurada O., Shinohara M., Reivich M., Jehle J. W. & Sokoloff L. (1976) Proc. natn. Acad. Sci., U.S.A. 73: 4230– 4234. Kety S. S. (1950) Am. J. Med. 8: 205– 217. Kety S. S. (1957) in The Metabolism of the Nervous System ( D. Richter, ed.) pp. 221– 237. Pergamon Press, London . Landau W. H., Freygang W. H., Rowland L. P., Sokoloff L. & Kety S. S. (1955) Trans. Am. Neurol. Ass. 80: 125– 129. Lashley K. S. (1934) J. comp. Neurol. 59: 341– 373. Lassen N. A. (1959) Physiol. Rev. 39: 183– 238. Montero V. M. & Guillery R. W. (1968) J. comp. Neurol. 134: 211– 242. Oldendorf W. H. (1971) Am. J. Physiol, 221: 1629– 1638. Plum F., Gjedde A. & Samson F. E. (1976) Neurosci. Res. Prog. Bull. 14: 457– 518. Rakic P. (1976) Nature 261: 467– 471. Reivich M., Jehle J. W., Sokoloff L. & Kety S. S. (1969) J. Appl. Physiol. 27: 296– 300. Roth R. H. (1976) Pharmac. Ther. 2: 71– 88. Sakurada O., Shinohara M., Klee W. A., Kennedy C. & Sokoloff L. (1976) Neurosci. Abstr. 2 (Part 1). 613. Schwartz W. J., Sharp F. R., Gunn R. H. & Evarts E. V. (1976) Nature 261: 155– 157. Shapiro H. M., Greenberg J. H., Reivich M., Shipko H., Van Horn K. & Sokoloff L. (1975) in Blood Flow and Metabolism in the Bruin ( A. M. Harper, W. B. Jennett, J. D. Miller & J. O. Rowan, eds.) pp. 9.42– 9.43. Churchill Livingstone, Edinburgh . Sharp F. R., Kauer J. S. & Shepherd G. M. (1975) Brain Res. 98: 596– 600. Shinohara M., Sakurada O., Jehle J. & Sokoloff L. (1976) Neurosci. Abstr. 2 (Part 1). 615. Sokoloff L. (1969) in Psychochemical Research in Man ( A. J. Mandell & M. P. Mandell, eds.) pp. 237– 252. Academic Press, New York . Sokoloff L. (1976) in Basic Neurochemistry ( G. J. Siegel, R. W. Albers, R. Katzman & B. W. Agranoff, eds.) 2nd ed, pp. 388– 413. Little, Brown, Boston . Sokoloff L., Reivich M., Kennedy C., Des Rosiers M. H., Patlak C. S., Pettigrew K. D., Sakurada O. & Shinohara M. (1977) J. Neurochem. 28: 897– 916. Sols A. & Crane R. K. (1954) J. biol. Chem. 210: 581– 595. Wiesel T. N., Hubel D. H. & Lam D. M. K. (1974) Brain Res. 79: 273– 279. Wolfson L. I. & Brown L. (1976) Neurosci. Abstr. 2 (Part 1), 510. Wolfson L. I., Sakurada O. & Sokoloff L. (1976) Trans. Am. Soc. Neurochem. 7, 165. Citing Literature Volume29, Issue1July 1977Pages 13-26 ReferencesRelatedInformation
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The glucose borne by the blood accounts for 99% of the brain energy requirements.
“The fact that the maintenance of peripheral glucose levels would impact brain function, although not well described among normal elderly prior to this study, is not surprising, given that the glucose borne by the blood accounts for 99% of the brain energy requirements (26).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [26]
The measurements of glucose utilization in all species are directly comparable.
“In those studies, the measurements of glucose utilization in all species were performed by [14C]2-deoxyglucose uptake [4] in mouse, rat, squirrel and macaque monkey, or by the similar method of [18F]fluoro-2-deoxy-D-glucose uptake [66] in baboon, human, and one case of macaque, and are thus directly comparable.”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [4]
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- Authors
- Sokoloff, L.
- Affiliations
- United States Public Health Service (US)
- Corresponding author
- Sokoloff, Louis
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1977-07
- Volume
- 29
- Issue
- 1
- Pages
- 13-26
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2035183926
- Cited by
- 807
- References
- 22
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 14 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 19 · 2012: 18
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Profiles in Science (submittedVersion, public-domain)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- energy metabolism, central nervous system, brain glucose metabolism, physiological function, brain energy supply, cerebral blood flow
- MeSH terms
- Anesthesia, General, Animals, Haplorhini, Brain, Deoxyglucose, Energy Metabolism, Macaca mulatta, Mathematics, Models, Biological, Motor Cortex, Olfactory Nerve, Organ Specificity, Penicillins, Sciatic Nerve, Rats
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