The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
High‐ and Low‐Affinity Transport of D‐Glucose from Blood to Brain
Abstract
Abstract: Measurements of the unidirectional blood‐brain glucose flux in rat were incompatible with a single set of kinetic constants for transendothelial transport. At least two transfer mechanisms were present: a high‐affinity, low‐capacity system, and a low‐affinity, high‐capacity system. The low‐affinity system did not represent passive diffusion because it distinguished between D‐and L‐glucose. The T max and Km, for the high‐affinity system were 0.16 mmol 100 g−1 min−1 and 1 mM; for the low‐affinity system, ∼ 5 mmol 100 g−1 min−1 and ∼ 1 M. With these values, physiological glucose concentrations were not sufficient to saturate the low‐affinity system. In normoglycemia, therefore, three independent pathways of glucose transport from blood to brain appear to exist: a high‐affinity facilitated diffusion pathway of apparent permeability 235·10−7 cm s−1, a specific but nonsaturable diffusion pathway of permeability 85·10−7 cm s−l, and a nonspecifc passive diffusion pathway of permeability 2·10−7 cm s−1.
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THE INHIBITION OF CHOLINESTERASE BY PHYSOSTIGMINE AND PROSTIGMINE
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Transport of glucose from blood to brain.
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Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
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Self-citationCARRIER MEDIATED BLOOD‐BRAIN BARRIER TRANSPORT OF CHOLINE AND CERTAIN CHOLINE ANALOGS
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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Glucose and ketone body utilization by the brain of neonatal rats
Nehlig, A., & Pereira de Vasconcelos, A. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90022-k · Cited by 276
Kutuzov, N., Flyvbjerg, H., & Lauritzen, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802155115 · Cited by 250
(1993) · PubMed · Cited by 197
Cerebrovascular Permeability Coefficients to Sodium, Potassium, and Chloride
Smith, Q. R., & Rapoport, S. I. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb08491.x · Cited by 196
Metadata
- Authors
- Gjedde, A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1981-04
- Volume
- 36
- Issue
- 4
- Pages
- 1463-1471
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1981940481
- Cited by
- 324
- References
- 21
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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