The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS
Abstract
Abstract— The kinetics of the uptake from blood to brain of pyruvate, lactate and glucose have been determined in rats of different ages. The carotid artery single injection technique was used in animals anaesthetized with pentobarbital. The rates of influx for each substrate were determined over a range of concentrations for the different age‐groups. Data were analysed in terms of the Michaelis‐Menten equation with a component to allow for non‐saturable diffusion. Values are given for Km, Vmax and Kd. In suckling rats (15‐21 days) the Vmax values for both pyruvate and lactate were 2.0 μmol g−1 min−1. In 28‐day‐old rats the Vmax values had fallen to one‐half and in adults they were less than one‐tenth. Km, values were higher in the younger animals. The rate of glucose transport in suckling rats was half that of 28‐day‐old and adults although there was no difference with age in the Km values. The results are discussed in relation to the net flux of these substrates in and out of brain during different stages of post‐natal development.
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Citations
Cites
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,683
Self-citationAmino acid assignment to one of three blood-brain barrier amino acid carriers
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Self-citationKetone-body utilization by adult and suckling rat brain in vivo
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Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
Oldendorf, W. H. (1970) · Brain Research · doi:10.1016/0006-8993(70)90123-x · Cited by 548
Self-citationTRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER1
Pardridge, W. M., & Oldendorf, W. H. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb07702.x · Cited by 535
Self-citationCarrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
Oldendorf, W. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.6.1450 · Cited by 463
Self-citationFacilitated transfer of glucose from blood into brain tissue.
Crone, C. (1965) · The Journal of Physiology · doi:10.1113/jphysiol.1965.sp007748 · Cited by 442
NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION1
Fernstrom, J. D., & Faller, D. V. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb10489.x · Cited by 423
Control of brain neurotransmitter synthesis by precursor availability and nutritional state
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Kinetics of blood-brain barrier transport of hexoses
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Cited by
Drug Transport across the Blood–Brain Barrier
Pardridge, W. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.126 · Cited by 1,994
Self-citationLactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571
Ohtsuki, S., & Terasaki, T. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9374-5 · Cited by 454
Role of Monocarboxylate Transporters in Drug Delivery to the Brain
Vijay, N., & Morris, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990462 · Cited by 408
Metadata
- Authors
- Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1979-08
- Volume
- 33
- Issue
- 2
- Pages
- 439-445
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2075008436
- Cited by
- 263
- References
- 26
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS. https://app.cochat.ai/papers/10.1111/j.1471-4159.1979.tb05173.x
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- Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H. (1979). KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1979.tb05173.x
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