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Cited by 263

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS

Cremer, Jill E., Cunningham, Vincent J., Pardridge, William M., Braun, Leon D., Oldendorf, William H.·1979·Journal of Neurochemistry

Abstract

Abstract— The kinetics of the uptake from blood to brain of pyruvate, lactate and glucose have been determined in rats of different ages. The carotid artery single injection technique was used in animals anaesthetized with pentobarbital. The rates of influx for each substrate were determined over a range of concentrations for the different age‐groups. Data were analysed in terms of the Michaelis‐Menten equation with a component to allow for non‐saturable diffusion. Values are given for Km, Vmax and Kd. In suckling rats (15‐21 days) the Vmax values for both pyruvate and lactate were 2.0 μmol g−1 min−1. In 28‐day‐old rats the Vmax values had fallen to one‐half and in adults they were less than one‐tenth. Km, values were higher in the younger animals. The rate of glucose transport in suckling rats was half that of 28‐day‐old and adults although there was no difference with age in the Km values. The results are discussed in relation to the net flux of these substrates in and out of brain during different stages of post‐natal development.

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Crossref · 10.1111/j.1471-4159.1979.tb05173.x

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Metadata

Authors
Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1979-08
Volume
33
Issue
2
Pages
439-445
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2075008436
Cited by
263
References
26
FWCI
5.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS. https://app.cochat.ai/papers/10.1111/j.1471-4159.1979.tb05173.x
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Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H. (1979). KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1979.tb05173.x

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