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Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites
Abstract
Abstract:In rat striatal membranes, NaCl induced a twofold increase in the maximal number of cocaine binding sites but did not alter the affinity of these sites for cocaine. This effect was concentration‐dependent, specific to sodium ions, and occurred in membranes prepared from corpus striatum but not from other brain regions. Lesions with 6‐hydroxydopamine but not with kainic acid eliminated the sodium‐induced increase in binding and produced a decrease in the Bmax of binding measured in the presence of NaCl. The capacity of a series of drugs to interfere with Na+–dependent cocaine binding correlated well with their capacity to inhibit [3 H]dopamine uptake into rat striatal synaptosomes. The present results suggest that Na+–dependent cocaine binding sites are localized presynaptically on dopaminergic nerve terminals in corpus striatum, and may be related to dopamine uptake sites.
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Cited by
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine
Hooks, M. S., Jones, G. H., Smith, A. D., Neill, D. B., & Justice, J. B. (1991) · Synapse · doi:10.1002/syn.890090206 · Cited by 293
Reith, M. E. A., Meisler, B. E., Sershen, H., & Lajtha, A. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90148-6 · Cited by 289
Goeders, N. E., & Guerin, G. F. (1994) · Psychopharmacology · doi:10.1007/bf02245445 · Cited by 288
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239
Metadata
- Authors
- Kennedy, L. T., & Hanbauer, I.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1983-01
- Volume
- 41
- Issue
- 1
- Pages
- 172-178
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1998128937
- Cited by
- 255
- References
- 0
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kennedy, L. T., & Hanbauer, I. (1983). Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1983.tb13666.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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