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An Excitant Amino Acid Projection from the Medial Prefrontal Cortex to the Anterior Part of Nucleus Accumbens in the Rat
Abstract
Abstract: High‐affinity uptake of neurotransmitter substrates in synaptosome‐containing homogenates and tissue concentrations of amino acids were examined in subcortical areas 5–6 days after bilateral N‐methyl‐D‐aspartate lesions confined to rat medial prefrontal cortex. D‐[3 H]Aspartate (32% of control) and [3 H]γ‐aminobutyric acid ([3 H]GABA) (60% of control) uptakes were significantly reduced in medial prefrontal cortex, whereas [3 H]choline (110% of control) uptake was unchanged, suggesting the production of axon‐sparing lesions. The uptake of D‐[3 H]aspartate (76% of control), but not of [3 H]GABA or [3 H]choline, was significantly reduced in nucleus accumbens, with no concomitant reduction in amino acid concentrations. When examined in serial coronal sections, reduced D‐[3 H]aspartate uptake was confined to the most anterior 500 μm of nucleus accumbens (67% of contralateral sample). No significant reductions of uptake or amino acid concentrations were observed in caudate putamen or ventral tegmental area. These results suggest a role for glutamate or aspartate as neurotransmitters in projections from medial prefrontal cortex to anterior nucleus accumbens. Medial prefrontal cortex may represent the major excitatory cortical input to the nucleus accumbens.
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“The PFC furthermore sends out glutamatergic afferents to the VTA as well as to the nucleus accumbens modulating dopaminergic signaling [204–206].”
From Development of prefrontal cortex (2022) · cites this paper as [205]
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Cites
Glutamate: A Neurotransmitter in Mammalian Brain
Fonnum, F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb09689.x · Cited by 2,008
Paxinos, G., & WATSON, C. R. R. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-547620-1.50007-2 · Cited by 824
Beckstead, R. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901840104 · Cited by 792
Amino acid neurotransmitters and their pathways in the mammalian central nervous system
Fagg, G. E., & Foster, A. C. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90263-4 · Cited by 651
Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats
PYCOCK, C., Kerwin, R. W., & Carter, C. J. (1980) · Nature · doi:10.1038/286074a0 · Cited by 550
Fonnum, F., Storm‐Mathisen, J., & Divac, I. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90168-8 · Cited by 541
A glutamatergic corticostriatal path?
McGeer, P. L., McGeer, E. G., Scherer, U., & Singh, K. (1977) · Brain Research · doi:10.1016/0006-8993(77)91003-4 · Cited by 486
High affinity uptake of glutamate in terminals of corticostriatal axons
Divac, I., Fonnum, F., & Storm‐Mathisen, J. (1977) · Nature · doi:10.1038/266377a0 · Cited by 478
PYCOCK, C., Carter, C., & Kerwin, R. W. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb04625.x · Cited by 246
Excitatory amino acid analogues: Neurotoxicity and seizures
Zaczek, R. C., & Coyle, J. T. (1982) · Neuropharmacology · doi:10.1016/0028-3908(82)90205-2 · Cited by 187
Research works printed but not linked: 1
- Carter C. J., 1980, Glutamatergic pathways from the medial prefrontal cortex to the anterior striatum, nucleus accumbens and substantia nigra, Br. J. Pharmacol., 70, 50P
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Carlson, J. N., & Glick, S. D. (1996) · Humana Press eBooks · doi:10.1007/978-1-59259-469-6_10 · Cited by 19
Glick, S. D., & Carlson, J. N. (1989) · Brain Research · doi:10.1016/0006-8993(89)91362-0 · Cited by 18
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Ikegami, A., & Duvauchelle, C. L. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)62002-2 · Cited by 18
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Olsen, C. M., & Duvauchelle, C. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03152-3 · Cited by 18
Brené, S., Herrera‐Marschitz, M., Persson, H., & Lindefors, N. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90258-5 · Cited by 18
Węzony, K., Czyrak, A., Maćkowiak, M., & Fijał, K. (1996) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169171 · Cited by 18
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Stein, E. A. (1993) · Synapse · doi:10.1002/syn.890130109 · Cited by 17
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Carlson, J. N., & Glick, S. D. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6732-9_10 · Cited by 17
Duvauchelle, C. L., Fleming, S. M., & Kornetsky, C. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00952-4 · Cited by 17
Duvauchelle, C. L., & Ettenberg, A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90027-y · Cited by 15
Asencio, H., Bustos, G., Gysling, K., & Labarca, R. (1991) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(91)90056-7 · Cited by 15
Ceci, A., & French, E. D. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90050-7 · Cited by 13
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Yang, Q., Moroji, T., Takamatsu, Y., Hagino, Y., & Okuwa, M. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90136-7 · Cited by 11
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Metadata
- Authors
- Christie, M. J., James, L. B., & Beart, P. M.
- Affiliations
- The University of Melbourne (AU)
- Australian National University (AU)
- Corresponding author
- Christie, M. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1985-08
- Volume
- 45
- Issue
- 2
- Pages
- 477-482
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1988715191
- Cited by
- 151
- References
- 24
- Citations by year
- 2021: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- medial prefrontal cortex, nucleus accumbens, glutamate, aspartic acid, excitatory amino acid neurotransmission, glutamatergic projections, NMDA lesions, GABA, choline
- MeSH terms
- Amino Acids, Animals, Aspartic Acid, Choline, Frontal Lobe, gamma-Aminobutyric Acid, Male, Neural Pathways, Nucleus Accumbens, Rats, Inbred Strains, Septal Nuclei, Synaptosomes, Neurotransmitter Agents, Rats
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