The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Extracellular Overflow of Neuroactive Amino Acids During Severe Insulin‐Induced Hypoglycemia: In Vivo Dialysis of the Rat Hippocampus
Abstract
Hypoglycemia‐evoked changes in levels of extracellular excitatory and inhibitory amino acids were studied using the microdialysis technique. A newly designed dialysis probe was inserted stereotaxically into the rat hippocampus. Animals were then subjected to insulin‐induced hypoglycemia; then blood glucose levels were restored by glucose injections after a 30‐min period of isoelectric electroencephalography. Dialysates were collected before, during, and after the isoelectric period. Amino acids in the dialysates were analyzed by liquid chromatography and fluorescence detection following automatic precolumn derivatization with o‐phthaldialdehyde. During the isoelectric phase, the concentration of aspartate increased 15‐fold, whereas glutamate, γ‐aminobutyric acid, taurine, and phosphoethanolamine levels were elevated three‐ to sixfold. Smaller increases were observed for nonneuroactive amino acids such as asparagine, alanine, and phenylalanine. In contrast to all other amino acids, the glutamine content was reduced to <30% of preisoelectric values. The concentrations of the neuroactive amino acids were restored to normal in the postisoelectric phase. These data demonstrate that there is an extracellular overflow of neuroactive amino acids, especially aspartate, during severe hypoglycemia.
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Cites
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Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain
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Self-citationCellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
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Benveniste, H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07243.x · Cited by 523
The role of calcium in apoptosis
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Metadata
- Authors
- Sandberg, M., Butcher, S. P., & Hagberg, H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1986-07
- Volume
- 47
- Issue
- 1
- Pages
- 178-184
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2153823370
- Cited by
- 344
- References
- 33
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sandberg, M., Butcher, S. P., & Hagberg, H. (1986). Extracellular Overflow of Neuroactive Amino Acids During Severe Insulin‐Induced Hypoglycemia: In Vivo Dialysis of the Rat Hippocampus. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1986.tb02847.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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