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Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus
Abstract
Abstract: Ibotenate, a rigid structural analogue of glutamate, markedly enhances the hydrolysis of membrane inositol phospholipids, as reflected by the stimulation of [3 H]inositol monophosphate formation in rat hippocampal slices prelabeled with [3 H]inositol and treated with Li+. Quisqualate, homocysteate, l‐glutamate, and l‐aspartate also induce a significant (albeit weaker) increase in [3 H]inositol monophosphate formation, whereas N‐methyl‐d‐aspartate, kainate, quinolinate, and N‐acetylaspartylglutamate are inactive. The increase in [3 H]inositol monophosphate formation elicited by the above‐mentioned excitatory amino acids is potently and selectively antagonized by dl‐2‐amino‐4‐phosphonobutyric acid, a dicarboxylic amino acid receptor antagonist. These results suggest that, in the hippocampus, a class of dicarboxylic amino acid recognition sites is coupled with phospholipase C, the enzyme that catalyzes the hydrolysis of membrane inositol phospholipids.
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Citations
Cited by
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,122
Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors
Schoepp, D., Bockaert, J., & Sladeczek, F. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90052-a · Cited by 462
Nicoletti, F., Wroblewski, J., Novelli, A., Alho, H., Guidotti, A., & Costa, E. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-07-01905.1986 · Cited by 451
Self-citationToward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome
Krueger, D. D., & Bear, M. F. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-061109-134644 · Cited by 259
Metadata
- Authors
- Nicoletti, F., Meek, J. L., Iadarola, M. J., Chuang, D. M., Roth, B. L., & Costa, E.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1986-01
- Volume
- 46
- Issue
- 1
- Pages
- 40-46
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2137376734
- Cited by
- 464
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Nicoletti, F., Meek, J. L., Iadarola, M. J., Chuang, D. M., Roth, B. L., & Costa, E. (1986). Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1986.tb12922.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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