The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells
Open accessAbstract
L-Glutamic, L-aspartic acids and a number of their structural analogs, including quisqualic, kainic, ibotenic, quinolinic, and N-methyl-D- aspartic (NMDA) acids, increase inositol phospholipid hydrolysis when added to primary cultures of cerebellar granule cells, as is reflected by an enhanced formation of 3H-inositolmonophosphate (3H-IP1) in the presence of Li+. L-Glutamic acid also enhances the formation of the initial products of inositol phospholipid hydrolysis, 3H-inositol di- (3H-IP2) and triphosphate (3H-IP3). In the absence of extracellular Ca2+, L-glutamic acid fails to enhance 3H-IP1 formation, but still increases 3H-IP2 and 3H-IP3 formation. The stimulation of 3H-IP1 formation elicited by L-glutamic acid is reduced by DL-2-amino-5- phosphonovaleric acid (APV) and gamma-glutamylglycine and, to a lesser extent, by 2,3-cis-piperidindicarboxylic acid (PDA). The stimulation of 3H-IP1 formation by kainic acid is antagonized by PDA and gamma- glutamylglycine, but it is almost unaffected by APV. The increase in 3H- IP1 formation elicited by quisqualic acid is not reduced by any of the dicarboxylic amino acid receptor antagonists that we have tested. We conclude that different subtypes of excitatory amino acid recognition sites are associated with inositol phospholipid metabolism in primary cultures of cerebellar granule cells.
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Inositol trisphosphate and diacylglycerol as second messengers
Berridge, M. J. (1984) · Biochemical Journal · doi:10.1042/bj2200345 · Cited by 3,516
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,491
Inositol phospholipids and cell surface receptor function
Michell, R. H. (1975) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(75)90017-9 · Cited by 2,470
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
Berridge, M. J., Downes, C. P., & Hanley, M. R. (1982) · Biochemical Journal · doi:10.1042/bj2060587 · Cited by 2,136
Turnover of Inositol Phospholipids and Signal Transduction
Nishizuka, Y. (1984) · Science · doi:10.1126/science.6147898 · Cited by 1,614
Foster, A. C., & Fagg, G. E. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90020-1 · Cited by 818
Einarsson, S., Josefsson, B., & Lagerkvist, S. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)91638-8 · Cited by 554
Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation
Brown, E., Kendall, D. A., & Nahorski, S. R. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02798.x · Cited by 517
Nicoletti, F., Meek, J. L., Iadarola, M. J., Chuang, D. M., Roth, B. L., & Costa, E. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb12922.x · Cited by 464
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Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,122
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662
Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors
Schoepp, D., Bockaert, J., & Sladeczek, F. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90052-a · Cited by 462
Heneka, M. T., L. Feinstein, D., Galea, E., Gleichmann, M., Wüllner, U., & Klockgether, T. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00192-7 · Cited by 150
Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization
Zorumski, C. F., & Thio, L. L. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90020-f · Cited by 118
Metadata
- Authors
- Nicoletti, F., Wroblewski, J., Novelli, A., Alho, H., Guidotti, A., & Costa, E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1986-07-01
- Volume
- 6
- Issue
- 7
- Pages
- 1905-1911
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1636078186
- Cited by
- 451
- References
- 13
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nicoletti, F., Wroblewski, J., Novelli, A., Alho, H., Guidotti, A., & Costa, E. (1986). The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.06-07-01905.1986
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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