The DOI matches its Crossref record.
Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines
Abstract
Abstract: In extensively washed rat cortical membranes [3 H](+)‐ 5 ‐ methyl ‐ 10,11 ‐ dihydro ‐ 5 H‐ dibenzo [a,d]cyclohepten‐5,10‐imine ([3 H]MK‐801) labeled a homogeneous set of sites (Bmax=1.86 pmol/mg protein) with relatively low affinity (KD= 45 n M). l‐Glutamate, glycine. and spermidine produced concentration‐dependent increases in specific [3 H]MK‐801 binding due to a reduction in the Kd of the radioligand. In the presence of high concentrations of l‐glutamate, glycine, or spermidine, the KD values for [3 H]MK‐801 were reduced to 11 n M, 18 n M, and 15 n M, respectively. Maximally effective concentrations of combinations of the three compounds further increased [3 H]MK‐801 binding affinity as follows: l‐glutamate + glycine, KD= 6.2 n M; l‐glutamate + spermidine, KD= 2.2 n M:
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 788
Interactions of polyamines with ion channels
WILLIAMS, K. (1997) · Biochemical Journal · doi:10.1042/bj3250289 · Cited by 498
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408
Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines
Traynelis, S. F., Hartley, M., & Heinemann, S. F. (1995) · Science · doi:10.1126/science.7754371 · Cited by 406
Metadata
- Authors
- Ransom, R. W., & Stec, N. L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1988-09
- Volume
- 51
- Issue
- 3
- Pages
- 830-836
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1964030958
- Cited by
- 750
- References
- 0
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines. https://app.cochat.ai/papers/10.1111/j.1471-4159.1988.tb01818.x
- The paper
- Ransom, R. W., & Stec, N. L. (1988). Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1988.tb01818.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
