The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence that Aspartate Aminotransferase Activity and Ketodicarboxylate Carrier Function Are Essential for Biosynthesis of Transmitter Glutamate
Abstract
Based on the selective inhibition of glutamate release in cerebellar granule cells in primary cultures by the aspartate aminotransferase inhibitor, aminooxyacetic acid, and by the ketodicarboxylate carrier inhibitor, phenylsuccinate, a novel model for synthesis of transmitter glutamate is suggested: Glutamate is formed from glutamine in the mitochondrial intramembrane space by phosphate‐activated glutaminase, transported across the inner membrane in exchange with aspartate, transaminated in the matrix to a‐ketoglutarate, which via the ketodicarboxylate carrier is transferred to the cytoplasm, and transaminated to form transmitter glutamate. Such a mechanism would explain the functional role of aspartate aminotransferase in glutamatergic neurons.
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Citations
Cites
Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures
Hertz, L., Drejer, J., & Schousboe, A. (1988) · Neurochemical Research · doi:10.1007/bf00973275 · Cited by 126
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Cited by
Beal, M. F. (1992) · Annals of Neurology · doi:10.1002/ana.410310202 · Cited by 961
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?
Lewerenz, J., & Maher, P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00469 · Cited by 718
Arginine metabolism and the synthesis of nitric oxide in the nervous system
Wiesinger, H. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00056-3 · Cited by 352
McKenna, M. C., Waagepetersen, H. S., Schousboe, A., & Sonnewald, U. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.011 · Cited by 328
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Metadata
- Authors
- Palaiologos, G., Hertz, L., & Schousboe, A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1988-07
- Volume
- 51
- Issue
- 1
- Pages
- 317-320
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2115099018
- Cited by
- 158
- References
- 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palaiologos, G., Hertz, L., & Schousboe, A. (1988). Evidence that Aspartate Aminotransferase Activity and Ketodicarboxylate Carrier Function Are Essential for Biosynthesis of Transmitter Glutamate. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1988.tb04872.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
