Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures
Abstract
Several aspects of energy metabolism (glucose utilization, lactate production, 14CO2 production from labeled glucose, glutamate or pyruvate, oxygen consumption and contents of ATP and phosphocreatine) were measured in cerebellar granule cells (glutamatergic) in primary cultures and compared with corresponding data for cerebral cortical neurons (mainly GABA-ergic) and astrocytes. Cerebellar granule cells and astrocytes were metabolically more active than cerebral cortical neurons. Glutamate which is utilized as a major metabolic fuel as astrocytes and, to a lesser extent, in cerebral cortical neurons, was virtually not oxidized in cerebellar granule cells.
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Astrocytes can produce lactate from glucose.
“Astrocytes can indeed produce lactate from glucose (Hertz et al., 1988; Magistretti et al., 1993), and this lactate production can be stimulated by glutamate and potassium, which become elevated during neuronal activity (Walz and Mukerji, 1988; Peng et al., 1994; Pellerin and Magistretti, 1996; Bittner et al., 2011).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Hertz et al., 1988
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- Authors
- Hertz, L., Drejer, J., & Schousboe, A.
- Affiliations
- University of Saskatchewan (CA)
- Ferrosan Medical Devices (Denmark) (DK)
- University of Copenhagen (DK)
- Venue
- Neurochemical Research
- Published
- 1988-07
- Volume
- 13
- Issue
- 7
- Pages
- 605-610
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2071145047
- Cited by
- 126
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- energy metabolism, cerebellar granule cells, GABAergic neurons, cortical neurons, astrocytes, glucose utilization, lactic acid production, oxygen consumption, ATP, phosphocreatine, glutamate oxidation, pyruvate
- MeSH terms
- Animals, Astrocytes, Cells, Cultured, Cerebellum, Cerebral Cortex, Energy Metabolism, gamma-Aminobutyric Acid, Glucose, Glutamates, Lactates, Neurons, Oxygen Consumption, Pyruvates, Glutamic Acid, Pyruvic Acid, Lactic Acid, Mice
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