The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Glycine Site Associated with N‐Methyl‐d‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists
Abstract
Abstract Membranes from rat telencephalon contain a single class of strychnine‐insensitive glycine sites. That these sites are associated with N‐methyl‐d‐aspartic acid (NMDA) receptors is indicated by the observations that [3 H]glycine binding is selectively modulated by NMDA receptor ligands and, conversely, that several amino acids interacting with the glycine sites increase [3 H]N‐[1‐(2‐thienyl)cyclohexyl]piper‐idine ([3 H]TCP) binding to the phencyclidine site of the NMDA receptor. The endogenous compound kynurenate and several related quinoline and quinoxaline derivatives inhibit glycine binding with affinities that are much higher than their affinities for glutamate binding sites. In contrast to glycine, kynurenate‐type compounds inhibit [3 H]TCP binding and thus are suggested to form a novel class of antagonists of the NMDA receptor acting through the glycine site. These results suggest the existence of a dual and opposite modulation of NMDA receptors by endogenous ligands.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Huettner, J. E., & Bean, B. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1307 · Cited by 751
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine
MacDonald, J. F., Miljkovic, Z., & Pennefather, P. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.58.2.251 · Cited by 387
Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35
Wang, J., Simonavicius, N., Wu, X., Swaminath, G., Reagan, J., Tian, H., & Ling, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603503200 · Cited by 687
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649
Young, A. B., & Fagg, G. E. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90199-i · Cited by 391
Lugo-Huitrón, R., Blanco-Ayala, T., Ugalde-Muñiz, P., Carrillo-Mora, P., Pedraza-Chaverrí, J., Silva-Adaya, D., Maldonado, P. D., Torres, I., Pinzón, E., Ortiz-Islas, E., et al. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.07.002 · Cited by 346
Metadata
- Authors
- Kessler, M., Terramani, T., Lynch, G., & Baudry, M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1989-04
- Volume
- 52
- Issue
- 4
- Pages
- 1319-1328
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2067494870
- Cited by
- 739
- References
- 3
- FWCI
- 30.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kessler, M., Terramani, T., Lynch, G., & Baudry, M. (1989). A Glycine Site Associated with N‐Methyl‐d‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1989.tb01881.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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