The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35
Open accessAbstract
Local catabolism of the essential amino acid tryptophan is considered an important mechanism in regulating immunological and neurological responses. The kynurenine pathway is the main route for the non-protein metabolism of tryptophan. The intermediates of the kynurenine pathway are present at micromolar concentrations in blood and are regulated by inflammatory stimuli. Here we show that GPR35, a previously orphan G protein-coupled receptor, functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G(qi/o) chimeric G proteins. Kynurenic acid stimulates [35S]guanosine 5'-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. Expression analysis indicates that GPR35 is predominantly detected in immune cells and the gastrointestinal tract. Furthermore, we show that kynurenic acid inhibits lipopolysaccharide-induced tumor necrosis factor-alpha secretion in peripheral blood mononuclear cells. Our results suggest unexpected signaling functions for kynurenic acid through GPR35 activation.
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Cited by
Kynurenines in the mammalian brain: when physiology meets pathology
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Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression
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Metadata
- Authors
- Wang, J., Simonavicius, N., Wu, X., Swaminath, G., Reagan, J., Tian, H., & Ling, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 281
- Issue
- 31
- Pages
- 22021-22028
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1984584304
- Cited by
- 687
- References
- 38
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, J., Simonavicius, N., Wu, X., Swaminath, G., Reagan, J., Tian, H., & Ling, L. (2006). Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m603503200
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