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An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro
Abstract
Abstract: To provide an “in vitro” system for studying brain capillary function, we have developed a process ofcoculture that closely mimics the “in vivo” situation by culturing brain capillary endothelial cells on one side of a filter and astrocytes on the other. Under these conditions, endothelial cells retain all the endothelial cell markers and the characteristics of the blood–brain barrier, including tight junctions and γ‐glutamyl transpeptidase activity. The average electric resistance for the monolayers was 661 Ω cm 2. The system is impermeable to inulin and sucrose but allows the transport of leucine. Arabinose treatment increases transcellular transport flux by 70%. The relative ease with which such monolayers can be produced in large quantities would facilitate the “in vitro” study of brain capillary functions.
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Citations
Cited by
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Astrocyte-endothelial Interactions and Blood-Brain Barrier Permeability*
Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00064.x · Cited by 1,168
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107
Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843
Self-citationTranscytosis: Crossing Cellular Barriers
TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681
Metadata
- Authors
- Dehouck, M., Méresse, S., Delorme, P., Fruchart, J., & Cecchelli, R.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1990-05
- Volume
- 54
- Issue
- 5
- Pages
- 1798-1801
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2055137108
- Cited by
- 547
- References
- 0
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dehouck, M., Méresse, S., Delorme, P., Fruchart, J., & Cecchelli, R. (1990). An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1990.tb01236.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
