Transcytosis: Crossing Cellular Barriers

TUMA, PAMELA L.; HUBBARD, ANN L.

doi:10.1152/physrev.00001.2003

Cited by 681Cellular transport and secretionCaveolin-1 and cellular processesBarrier Structure and Function Studies

Transcytosis: Crossing Cellular Barriers

TUMA, PAMELA L., HUBBARD, ANN L.·2003·Physiological Reviews

DOI 10.1152/physrev.00001.2003

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Abstract

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev 83: 871–932, 2003; 10.1152/physrev.00001.2003.—Transcytosis, the vesicular transport of macromolecules from one side of a cell to the other, is a strategy used by multicellular organisms to selectively move material between two environments without altering the unique compositions of those environments. In this review, we summarize our knowledge of the different cell types using transcytosis in vivo, the variety of cargo moved, and the diverse pathways for delivering that cargo. We evaluate in vitro models that are currently being used to study transcytosis. Caveolae-mediated transcytosis by endothelial cells that line the microvasculature and carry circulating plasma proteins to the interstitium is explained in more detail, as is clathrin-mediated transcytosis of IgA by epithelial cells of the digestive tract. The molecular basis of vesicle traffic is discussed, with emphasis on the gaps and uncertainties in our understanding of the molecules and mechanisms that regulate transcytosis. In our view there is still much to be learned about this fundamental process.

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After binding to the apical side of M cells, macromolecules are endocytosed via clathrin-coated vesicles, reach the lysosomal compartment, and are exocytosed basolaterally to be taken up by APCs.
“Once bound to the apical side of M cells, macromolecules are endocytosed via clathrin-coated vesicles, thereby reaching the lysosomal compartment, from which they are exocytosed to the basolateral site to be taken up by antigen presenting cells (APCs) [34,35].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [35]

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Authors: TUMA, P. L., & HUBBARD, A. L.
Affiliations: Johns Hopkins University (US)
ORCID: TUMA, PAMELA L.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2003-07
Volume: 83
Issue: 3
Pages: 871-932
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00001.2003
OpenAlex: W2074782193
Cited by: 681
References: 644
Citations by year: 2026: 26 · 2025: 27 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 29 · 2020: 34 · 2019: 30 · 2018: 38 · 2017: 36 · 2016: 23 · 2015: 36 · 2014: 36 · 2013: 33 · 2012: 31
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01dk044375-10)
National Institute of General Medical Sciences (R01GM029185, R01-GM-29185)
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007632, 32-DK-07632, F32DK009620, DK-09620, P01 DK44375)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: transcytosis, vesicle trafficking, caveolae, endothelial cells, IgA, intestinal epithelial cells, interstitial fluid
MeSH terms: Animals, Biological Transport, Cell Physiological Phenomena, Humans, Transport Vesicles

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Transcytosis: Crossing Cellular Barriers

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