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Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains
Abstract
Abstract: Histochemical and biochemical determinations of total iron, iron (II), and iron (III) contents in brain regions from Parkinson's and Alzheimer's diseases have demonstrated a selective increase of total iron content in parkinsonian substantia nigra zona compacta but not in the zona reticulata. The increase of iron content is mainly in iron (III). The ratio of iron (II):iron (III) in zona compacta changes from almost 2:1 to 1:2. This change is thought to be relevant and may contribute to the selective elevation of basal lipid peroxidation in substantia nigra reported previously. Iron may be available in a free state and thus can participate in autooxidation of dopamine with the resultant generation of H 2 O 2 and oxygen free radicals.
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Citations
Cites
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301
Cited by
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Metadata
- Authors
- Sofic, E., Paulus, W., Jellinger, K., Riederer, P., & Youdim, M. B. H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1991-03
- Volume
- 56
- Issue
- 3
- Pages
- 978-982
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2156840897
- Cited by
- 524
- References
- 2
- FWCI
- 24.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Sofic, E., Paulus, W., Jellinger, K., Riederer, P., & Youdim, M. B. H. (1991). Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1991.tb02017.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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