The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter
Abstract
Abstract:Concurrent cocaine and alcohol use is common practice in the general population, as indicated by recent prevalence studies. In the presence of ethyl alcohol, cocaine is metabolized to its ethyl homolog, cocaethylene. The transesterification of cocaine and ethanol to cocaethylene takes place in the liver and represents a novel metabolic reaction. Cocaethylene was detected in postmortem blood, liver, and neurological tissues in concentrations equal to and sometimes exceeding those of cocaine. In vitro binding studies demonstrate that cocaethylene has a pharmacological profile similar but not identical to that of cocaine at monoamine transport sites assayed in the human brain. Cocaethylene was equipotent to cocaine at inhibiting [3 H]mazindol binding to the dopamine transporter. The blockade of dopamine reuptake in the synaptic cleft by cocaethylene may account for the enhanced euphoria associated with combined alcohol and cocaine abuse.
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Citations
Cites
Concurrent and simultaneous use of alcohol with cocaine: results of national survey
Grant, B. F., & Harford, T. C. (1990) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(90)90147-7 · Cited by 275
Cited by
Cardiovascular complications of cocaine use
Lange, R. A., & Hillis, L. D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108023450507 · Cited by 810
Stephens, B. G., Jentzen, J. M., Karch, S., Mash, D. C., & Wetli, C. V. (2004) · American Journal of Forensic Medicine & Pathology · doi:10.1097/01.paf.0000118960.58334.a9 · Cited by 84
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Metadata
- Authors
- Hearn, W. L., Flynn, D. D., Hime, G. W., Rose, S., Cofino, J. C., Mantero‐Atienza, E., Wetli, C. V., & Mash, D. C.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 56
- Issue
- 2
- Pages
- 698-701
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2039506066
- Cited by
- 293
- References
- 1
- FWCI
- 62.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter. https://app.cochat.ai/papers/10.1111/j.1471-4159.1991.tb08205.x
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- Hearn, W. L., Flynn, D. D., Hime, G. W., Rose, S., Cofino, J. C., Mantero‐Atienza, E., Wetli, C. V., & Mash, D. C. (1991). Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1991.tb08205.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
