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Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia
Abstract
Abstract: The expression of interleukin‐1β (IL‐1β) mRNA in the cerebral cortex, hippocampus, striatum, and thalamus of rats was studied after transient forebrain ischemia. IL‐1β mRNA was not detected in all these regions of sham‐operated control rats. IL‐1β mRNA was induced after transient forebrain ischemia and reached a detectable level in all regions examined 15 min after the start of recirculation. The induction of IL‐1β mRNA had a few peaks, that is, peaks were observed at 30 and 240 min in the four regions examined, and another peak was observed at 90 min in the striatum. One day after the start of recirculation, IL‐1β mRNA levels were markedly decreased, but even 7 days after that, IL‐1β mRNA was found at very low levels in all regions examined. The amounts of c‐fos and β‐actin mRNAs on the same blots were also examined. The induction of c‐fos mRNA was transient and had only one peak in all regions examined, whereas the levels of β‐actin mRNA in these regions were fairly constant throughout the recirculation period. Thus, we provide the first evidence for a characteristic expression of IL‐1β mRNA in several brain regions after transient forebrain ischemia.
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Cited by
Hara, H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., Shimizu-Sasamata, M., Yuan, J., & Moskowitz, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2007 · Cited by 834
“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
Vitkovic, L., Bockaert, J., & Jacque, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740457.x · Cited by 506
Toll-like receptors in the pathogenesis of neuroinflammation
Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331
Hepatic platelet and leukocyte adherence during endotoxemia
Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M.-M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275
Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
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Metadata
- Authors
- Minami, M., Kuraishi, Y., Yabuuchi, K., Yamazaki, A., & Satoh, M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 58
- Issue
- 1
- Pages
- 390-392
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2082011784
- Cited by
- 332
- References
- 0
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia. https://app.cochat.ai/papers/10.1111/j.1471-4159.1992.tb09324.x
- The paper
- Minami, M., Kuraishi, Y., Yabuuchi, K., Yamazaki, A., & Satoh, M. (1992). Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1992.tb09324.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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