Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology

Interleukin-1 and interleukin-1 antagonism

Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,303 · see citing works

Excitatory amino acid neurotoxicity and neurodegenerative disease

Meldrum, B. S., & Garthwaite, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90184-a · Cited by 1,774 · see citing works

Biology of interleukin 1

Dinarello, C. A. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.2.3277884 · Cited by 1,532 · see citing works

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472 · see citing works

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

Selmaj, K. W., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,357 · see citing works

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352 · see citing works

Characterization of ameboid microglia isolated from developing mammalian brain

Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300 · see citing works

Fever: Role of Pyrogens and Cryogens

Kluger, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.93 · Cited by 1,220 · see citing works

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C. (1990) · Blood · doi:10.1182/blood.v75.1.40.40 · Cited by 1,012 · see citing works

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006 · see citing works

Cytokines and the nervous system II: actions and mechanisms of action

Rothwell, N. J., & Hopkins, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93890-a · Cited by 922 · see citing works

Interleukin 1 of the central nervous system is produced by ameboid microglia.

Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859 · see citing works

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847 · see citing works

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta

Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C. F., & Berman, J. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2659 · Cited by 803 · see citing works

Cytokines and the nervous system I: expression and recognition

Hopkins, S. J., & Rothwell, N. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80029-2 · Cited by 793 · see citing works

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 759 · see citing works

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

Fontana, A., Kristensen, F., Dubs, R., Gemsa, D., & Weber, E. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2413 · Cited by 752 · see citing works

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

Dinarello, C. A., & Thompson, R. C. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90142-g · Cited by 729 · see citing works

The immune-hypothalamic-pituitary-adrenal axis.

Bateman, A., Singh, A., Kral, T., & Solomon, S. (1989) · Endocrine reviews · doi:10.1210/edrv-10-1-92 · Cited by 666 · see citing works

Regulation of ACTH Secretion: Variations on a Theme of B

DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · see citing works

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

Sawada, M., Kondo, N., Suzumura, A., & Marunouchi, T. (1989) · Brain Research · doi:10.1016/0006-8993(89)90078-4 · Cited by 631 · see citing works

Interleukin 1 signaling occurs exclusively via the type I receptor.

Sims, J. E., Gayle, M. A., Slack, J. L., Alderson, M. R., Bird, T. A., Giri, J. G., Colotta, F., Re, F., Mantovani, A., & Shanebeck, K. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6155 · Cited by 610 · see citing works

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

Giulian, D., Woodward, J., Young, D., Krebs, J., & Lachman, L. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02485.1988 · Cited by 583 · see citing works

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577 · see citing works

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

Engelmann, H., Novick, D., & Wallach, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40049-5 · Cited by 554 · see citing works

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

Relton, J. K., & Rothwell, N. J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90033-t · Cited by 548 · see citing works

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.

Selmaj, K. W., Farooq, M., Norton, W. T., Raine, C. S., & Brosnan, C. F. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.129 · Cited by 544 · see citing works

A Phase II Study of Moderate Hypothermia in Severe Brain Injury

Clifton, G. L., Allen, S. J., Barrodale, P. M., Plenger, P. M., BERRY, J., KOCH, S., Fletcher, J. M., Hayes, R. L., & Choi, S. C. (1993) · Journal of Neurotrauma · doi:10.1089/neu.1993.10.263 · Cited by 533 · see citing works

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

Layé, S., Parnet, P., Goujon, E., & Dantzer, R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90197-x · Cited by 500 · see citing works

Lipocortin and the mechanism of action of the glucocorticoids

Flower, R. J. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11614.x · Cited by 494 · see citing works

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works

Tumor necrosis factor-<i>alpha</i> production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 <i>beta</i>.

Chung, I. Y., & Benveniste, E. N. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.8.2999 · Cited by 481 · see citing works

Neuropoietic cytokines in the hematopoietic fold

Bazán, J. F. (1991) · Neuron · doi:10.1016/0896-6273(91)90258-2 · Cited by 473 · see citing works

Visualization and characterization of interleukin 1 receptors in brain.

Farrar, W. L., Kilian, P. L., Ruff, M. R., Hill, J. M., & Pert, C. B. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.2.459 · Cited by 458 · see citing works

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

Jirik, F. R., Podor, T. J., Hirano, T., Kishimoto, T., Loskutoff, D. J., Carson, D. A., & Lotz, M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.1.144 · Cited by 458 · see citing works

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

Dripps, D. J., Brandhuber, B. J., Thompson, R. C., & Eisenberg, S. P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99230-6 · Cited by 453 · see citing works

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

Selmaj, K. W., Raine, C. S., & Cross, A. H. (1991) · Annals of Neurology · doi:10.1002/ana.410300510 · Cited by 441 · see citing works

Therapeutic modulation of brain temperature: relevance to ischemic brain injury.

Ginsberg, M. D., Sternau, L., Globus, M. Y. ‐., et al. (1992) · PubMed · Cited by 428 · see citing works

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

Satoh, T., Nakamura, S., Taga, T., Matsuda, T., Hirano, T., Kishimoto, T., & Kaziro, Y. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3546-3549.1988 · Cited by 414 · see citing works

Interleukin 6 is involved in interleukin 1‐induced activities

Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409 · see citing works

Lipocortin-1: cellular mechanisms and clinical relevance

Flower, R., & Rothwell, N. J. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90281-x · Cited by 378 · see citing works

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

Wahlestedt, C., Golanov, E. V., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C. E., & Reis, D. J. (1993) · Nature · doi:10.1038/363260a0 · Cited by 372 · see citing works

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

Spranger, M., Lindholm, D., Bandtlow, C. E., Heumann, R., Gnahn, H., Näher‐Noé, M., & Thoenen, H. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00382.x · Cited by 371 · see citing works

Immunoreactive interleukin-1β localization in the rat forebrain

Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90445-h · Cited by 340 · see citing works

Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution

Souza, E. B. D. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00088.1987 · Cited by 338 · see citing works

Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

van Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91588-6 · Cited by 333 · see citing works

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

Minami, M., Kuraishi, Y., Yabuuchi, K., Yamazaki, A., & Satoh, M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09324.x · Cited by 332 · see citing works

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier

Banks, W. A., Kastin, A. J., & Durham, D. A. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90185-8 · Cited by 325 · see citing works

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

Vannier, E. G., Miller, L. C., & Dinarello, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4076 · Cited by 321 · see citing works

Functions and mechanisms of interleukin 1 in the brain

Rothwell, N. J. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90623-z · Cited by 321 · see citing works

Induction and regulation of interleukin-6 gene expression in rat astrocytes

Benveniste, E. N., Sparacio, S. M., Norris, J. G., Grenett, H. E., & Fuller, G. M. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90104-u · Cited by 314 · see citing works

Cytokines and the nervous system I: expression and recognition

HOPKINS, S. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93881-w · Cited by 309 · see citing works

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

Bluthé, R.-M., Dantzer, R., & Kelley, K. W. (1992) · Brain Research · doi:10.1016/0006-8993(92)90779-9 · Cited by 303 · see citing works

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Takei, N., & Hatanaka, H. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90132-8 · Cited by 301 · see citing works

Systematic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone

Dunn, A. J. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90522-x · Cited by 297 · see citing works

Reactive glia as rivals in regulating neuronal survival

Giulian, D. (1993) · Glia · doi:10.1002/glia.440070116 · Cited by 296 · see citing works

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

Hall, E. D., Yonkers, P. A., McCall, J. M., & Braughler, J. M. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.3.0456 · Cited by 295 · see citing works

Neuronal differentiation factors/cytokines and synaptic plasticity

Patterson, P. H., & Nawa, H. (1993) · Cell · doi:10.1016/s0092-8674(05)80032-7 · Cited by 288 · see citing works

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.

Piani, D., & Fontana, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3578 · Cited by 274 · see citing works

Receptors for interleukin-1 (α and β) in mouse brain: Mapping and neuronal localization in hippocampus

Ban, E., Milon, G., Prudhomme, N., Fillion, G., & Haour, F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90412-h · Cited by 270 · see citing works

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

Vandenabeele, P., & Fiers, W. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90032-o · Cited by 264 · see citing works

Role of neurotrophins in mouse neuronal development

Klein, R. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.10.8050673 · Cited by 260 · see citing works

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

Benveniste, E. N., & Merrill, J. E. (1986) · Nature · doi:10.1038/321610a0 · Cited by 254 · see citing works

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

Toulmond, S., & Rothwell, N. J. (1995) · Brain Research · doi:10.1016/0006-8993(94)01343-g · Cited by 251 · see citing works

Models of neuronal injury in AIDS: another role for the NMDA receptor?

Lipton, S. A. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90013-x · Cited by 245 · see citing works

Glucocorticoid mechanisms in acute spinal cord injury: A review and therapeutic rationale

Hall, E. D., & Braughler, J. M. (1982) · Surgical Neurology · doi:10.1016/0090-3019(82)90140-9 · Cited by 239 · see citing works

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

Gadient, R. A., Cron, K., & Otten, U. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90687-5 · Cited by 233 · see citing works

Elevation of tumor necrosis factor in head injury

Goodman, J. C., Robertson, C. S., Grossman, R. G., & Narayan, R. K. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90105-v · Cited by 224 · see citing works

Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta.

Matsushima, K., Akahoshi, T., Yamada, M., et al. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4496 · Cited by 220 · see citing works

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

Strijbos, P. J. L. M., & Rothwell, N. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03468.1995 · Cited by 214 · see citing works

Cytokine Regulation of Neuronal Survival

Brenneman, D. E., Schultzberg, M., Bartfai, T., & Gozes, I. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09743.x · Cited by 210 · see citing works

Product ion of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes

Fábry, Z., Fitzsimmons, K. M., Herlein, J. A., Moninger, T. O., Dobbs, M. B., & HART, M. N. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90281-3 · Cited by 207 · see citing works

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

Schöbitz, B., Voorhuis, D. A. M., & de Kloet, E. R. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90046-a · Cited by 200 · see citing works

Tumor Necrosis Factor-α is a Potent ACTH Secretagogue: Comparison to Interleukin-1β

Sharp, B. M., Matta, S. G., Peterson, P. K., Newton, R. C., Chao, C. C., & McAllen, K. (1989) · Endocrinology · doi:10.1210/endo-124-6-3131 · Cited by 193 · see citing works

Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

Araujo, D., & Cotman, C. W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01668.1992 · Cited by 193 · see citing works

Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha.

Norris, J., Tang, L., Sparacio, S. M., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.841 · Cited by 193 · see citing works

Central effects of CRF on metabolism and energy balance

Rothwell, N. J. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80037-5 · Cited by 189 · see citing works

Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat

Coceani, F., Lees, J., & Dinarello, C. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90883-9 · Cited by 178 · see citing works

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

Araujo, D. M., Lapchak, P. A., Collier, B., & Quirion, R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91104-9 · Cited by 177 · see citing works

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

Miller, L. G., Galpern, W. R., Dunlap, K., Dinarello, C. A., & Turner, T. J. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10887-0 · Cited by 170 · see citing works

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

Turner, M., Chantry, D., Katsikis, P. D., et al. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210708 · Cited by 163 · see citing works

Expression of cytokine receptors in cultured neuronal and glial cells

Sawada, M., Itoh, Y., Suzumura, A., & Marunouchi, T. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90396-3 · Cited by 160 · see citing works

Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.

Andersson, P.-B., Perry, V. H., & Gordon, S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.1.255 · Cited by 158 · see citing works

Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons

Toulmond, S., Vigé, X., Fage, D., & Bénavidès, J. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90713-h · Cited by 155 · see citing works

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

Čarman‐Kržan, M., Vigé, X., & Wise, B. C. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08197.x · Cited by 150 · see citing works

Interleukin-6 is a centrally acting endogenous pyrogen in the rat

Rothwell, N. J., Busbridge, N. J., Feuvre, R. A. L., Hardwick, A. J., Gauldie, J., & Hopkins, S. J. (1991) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y91-219 · Cited by 147 · see citing works

Expression of type I and type II interleukin-1 receptors in mouse brain

Parnet, P., Amindari, S., Wu, C., Brunke-Reese, D., Goujon, E., Weyhenmeyer, J. A., Dantzer, R., & Kelley, K. W. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90185-6 · Cited by 145 · see citing works

Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.

Hall, E. D., & Yonkers, P. A. (1988) · Stroke · doi:10.1161/01.str.19.3.340 · Cited by 139 · see citing works

NGF and the local control of nerve terminal growth

Campenot, R. B. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250603 · Cited by 138 · see citing works

Interleukin-1β inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C

Plata‐Saláman, C. R., & ffrench‐Mullen, J. M. H. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90202-x · Cited by 137 · see citing works

CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat

Rothwell, N. J. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.1.e111 · Cited by 134 · see citing works

Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain.

Relton, J. K., Strijbos, P. J. L. M., O’Shaughnessy, C. T., Carey, F., Forder, R. A., Tilders, F. J. H., & Rothwell, N. J. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.2.305 · Cited by 133 · see citing works

Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus

Tancredi, V., Zona, C., Velotti, F., Eusebi, F., & Santoni, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91331-a · Cited by 121 · see citing works

Identification of soluble interleukin-1 binding protein in cell-free supernatants. Evidence for soluble interleukin-1 receptor.

Giri, J. G., Newton, R. C., & Horuk, R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38176-6 · Cited by 114 · see citing works

Interleukin-6 is pyrogenic but not somnogenic

Opp, M. R., Obál, F., Cady, A. B., Johannsen, L., & Krueger, J. M. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90239-4 · Cited by 112 · see citing works

Interferons in Multiple Sclerosis

PANITCH, H. S. (1992) · Drugs · doi:10.2165/00003495-199244060-00004 · Cited by 107 · see citing works

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.

Hall, E. D., MCCALL, J. M., Chase, R. L., et al. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39043-9 · Cited by 104 · see citing works

Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats

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